Antimicrobial and antibiofilm properties of selenium-chitosan-loaded salicylic acid nanoparticles for the removal of emerging contaminants from bacterial pathogens

• Published in: World journal of microbiology & biotechnology 2024-03, Vol.40 (3), p.86-86, Article 86
• Main Authors: Bagherian, Mahla Sadat, Zargham, Parisa, Zarharan, Hoda, Bakhtiari, Maleknaz, Mortezaee Ghariyeh Ali, Negin, Yousefi, Ehsan, Es-haghi, Ali, Taghavizadeh Yazdi, Mohammad Ehsan
• Format: Article
• Language: English
• Subjects: Anti-Infective Agents - pharmacology; Applied Microbiology; Bacillus subtilis; Bacteria; Biochemistry; Biofilms; Biomedical and Life Sciences; Biotechnology; Chitosan; Chitosan - pharmacology; Contaminants; E coli; Environmental Engineering/Biotechnology; Escherichia coli; Field emission microscopy; Fourier transforms; Grain size; Infrared spectroscopy; Life Sciences; Microbial contamination; Microbiology; Microorganisms; Microscopy; Nanoparticles; Pseudomonas aeruginosa; Salicylic acid; Salicylic Acid - pharmacology; Selenium; Selenium - pharmacology; Stabilizers (agents); Staphylococcus aureus; Synthesis; Transmission electron microscopy; X ray powder diffraction; X-ray diffraction
• ISSN: 0959-3993; 1573-0972
• DOI: 10.1007/s11274-024-03917-z

In this study salicylic acid loaded containing selenium nanoparticles was synthesized and called SA@CS-Se NPs. the chitosan was used as a natural stabilizer during the synthesis process. Fourier transforms infrared spectroscopy (FTIR), Powder X-ray diffraction (XRD), field emission electron microscopy (FESEM), and transmission electron microscopy (TEM) were used to describe the physicochemical characteristics of the SA@CS-Se NPs. The PXRD examination revealed that the grain size was around 31.9 nm. TEM and FESEM techniques showed the spherical shape of SA@CS-Se NPs. Additionally, the analysis of experiments showed that SA@CS-Se NPs have antibacterial properties against 4 ATCC bacteria; So that with concentrations of 75, 125, 150, and 100 µg/ml, it inhibited the biofilm formation of Escherichia coli , Pseudomonas aeruginosa , Bacillus subtilis , and Staphylococcus aureus respectively. Also, at the concentration of 300 µg/ml, it removed 22.76, 23.2, 10.62, and 18.08% biofilm caused by E. coli , P. aeruginosa , B. subtilis , and S. aureus respectively. The synthesized SA@CS-Se NPs may find an application to reduce the unsafe influence of pathogenic microbes and, hence, eliminate microbial contamination.