Risk Index Predicts Pediatric Heart Allograft Non‐Utilization

Background Children listed for heart transplantation face the highest waitlist mortality among all solid organ transplant patients (14%). Attempts at decreasing donor allograft non‐utilization (41.5%) could potentially decrease waitlist mortality for pediatric heart transplant patients. Our aim was...

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Bibliographic Details
Published in:Pediatric transplantation 2024-02, Vol.28 (1), p.e14629-n/a
Main Authors: Lynn, Jake, Malik, Tahir, Montgomery, Ashley, Lang, Anna, Shamapant, Nikhil, Miggins, John, Kamepalli, Spoorthi, Goss, John, Rana, Abbas
Format: Article
Language:English
Subjects:
Adolescent
allograft non‐utilization
Allografts
Child
Ejection fraction
Heart
Heart Transplantation
Hepatitis
Hepatitis B
Hepatitis C
Humans
Mortality
Organ donors
Patients
pediatric heart transplantation
pediatric non‐utilization risk index
Pediatrics
Regression analysis
Retrospective Studies
Risk Factors
Stroke Volume
Tissue Donors
Transplants & implants
Ventricle
Ventricular Function, Left
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Summary:Background Children listed for heart transplantation face the highest waitlist mortality among all solid organ transplant patients (14%). Attempts at decreasing donor allograft non‐utilization (41.5%) could potentially decrease waitlist mortality for pediatric heart transplant patients. Our aim was to quantify the non‐utilization risk of pediatric donor heart allografts at the time of initial offering. Methods Using the United Network of Organ Sharing (UNOS) database, we retrospectively analyzed 8823 deceased donors (≤18 years old) data through univariable and multivariable analysis and logistic regression models. These factors were divided into a training (n = 5882) and validation set (n = 2941). Donor clinical characteristics and laboratory values were used to predict non‐utilization of donor hearts. The multivariable analysis used factors that were significant from the univariable analysis (p‐value 
ISSN:1397-3142
1399-3046
DOI:10.1111/petr.14629