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A Pd‐Catalyzed Annulation Strategy to Linearly Fused Functionalized N‐Heterocycles
Linearly fused polycyclic piperidines represent common substructures in natural products and biologically active small molecules. We have devised a Pd‐catalyzed annulation strategy to these compounds that converts readily available 2‐tetralones and indanones into these scaffolds with the potential f...
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| Published in: | Chemistry : a European journal 2024-04, Vol.30 (21), p.e202400116-n/a |
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| Main Authors: | , , , , |
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| Language: | English |
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| container_end_page | n/a |
| container_issue | 21 |
| container_start_page | e202400116 |
| container_title | Chemistry : a European journal |
| container_volume | 30 |
| creator | Hoteite, Larry Allen, Benjamin D. W. Elhajj, Ms. Ergaiya A. Meijer, Anthony J. H. M. Harrity, Joseph P. A. |
| description | Linearly fused polycyclic piperidines represent common substructures in natural products and biologically active small molecules. We have devised a Pd‐catalyzed annulation strategy to these compounds that converts readily available 2‐tetralones and indanones into these scaffolds with the potential for control of both enantio‐ and diastereoselectivity. Importantly, these compounds can be chemoselectively functionalized, providing an efficient and robust methodology to these important nitrogen‐containing molecules.
We report a stereoselective Pd‐catalyzed annulation strategy to linearly fused polycyclic piperidines from readily available substrates. These products can be chemoselectively functionalized to generate analogs that represent common substructures in bioactive compounds. |
| doi_str_mv | 10.1002/chem.202400116 |
| format | article |
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| fulltext | fulltext |
| identifier | ISSN: 0947-6539 |
| ispartof | Chemistry : a European journal, 2024-04, Vol.30 (21), p.e202400116-n/a |
| issn | 0947-6539 1521-3765 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2922951548 |
| source | Wiley-Blackwell Read & Publish Collection |
| subjects | allylic alkylation Biological activity catalysis Chemical reactions diastereoselective enantioselective Natural products Organic chemistry piperidine Stereoselectivity |
| title | A Pd‐Catalyzed Annulation Strategy to Linearly Fused Functionalized N‐Heterocycles |
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