Role of lymphatic endothelium specific hyaluronan receptor 1 in virus infection and associated diseases

Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE‐1) serves as a prominent marker for lymphatic endothelial cells (LECs) and is pivotal in the process of lymphangiogenesis, a critical factor in cancer development and metastasis. Overexpression of LYVE‐1 has been observed in various cancers, w...

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Bibliographic Details
Published in:Journal of medical virology 2024-02, Vol.96 (2), p.e29457-n/a
Main Authors: Dai, Lu, Qin, Zhiqiang
Format: Article
Language:English
Subjects:
Cancer
Cell migration
Cell proliferation
Endothelial cells
Endothelial Cells - pathology
Endothelium
Endothelium, Lymphatic - metabolism
Herpes viruses
Humans
hyaluronan
Hyaluronan Receptors - metabolism
Hyaluronic acid
Kaposi's sarcoma
Kaposi's sarcoma herpesvirus
Lymph nodes
lymphaangiogenesis
lymphatic vessel endothelial hyaluronan receptor 1
Metastases
Neoplasms - pathology
Pathogenesis
Receptors
Sarcoma
Tumorigenesis
Viral infections
virus
Virus Diseases - pathology
Viruses
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Summary:Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE‐1) serves as a prominent marker for lymphatic endothelial cells (LECs) and is pivotal in the process of lymphangiogenesis, a critical factor in cancer development and metastasis. Overexpression of LYVE‐1 has been observed in various cancers, where it is recognized as an adverse prognostic indicator. Targeting LYVE‐1 has demonstrated inhibitory effects on tumor cell proliferation, migration, and the formation of lymph node metastases both in vitro and in vivo. While extensive research has focused on the role of LYVE‐1 in cancer cells, its involvement in virus infection and associated diseases remains largely unexplored. This review consolidates recent findings regarding the expression of LYVE‐1 and its functions in lymphangiogenesis during various viral infections and the development of related diseases, with a particular emphasis on Kaposi's sarcoma herpesvirus. Despite the limited available data, it is evident that further studies are essential to comprehensively understand the contribution of LYVE‐1 to viral pathogenesis and oncogenesis.
ISSN:0146-6615
1096-9071
DOI:10.1002/jmv.29457