Pigmented dentinogenic ghost cell tumor: a unique case report and a review of the literature

Dentinogenic ghost cell tumors are rare tumors, and few cases of them were reported in the literature. The presence of pigment in odontogenic lesions is a rare unexplained histological finding. In this report, we describe a unique case of a 7-year-old girl that was referred to the Department of Oral...

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Bibliographic Details
Published in:Virchows Archiv : an international journal of pathology 2024-04, Vol.484 (4), p.703-708
Main Authors: Mohamed, Yassmin Abdalla Mustafa, Yousif, Mohamed Mogahid Abdelrahman, Elbashir, Nazik Omer, Ahmed, Abeer Hemedan Mohammed, Ali, Ahmed Eltayeb, Suleiman, Ahmed Mohamed
Format: Article
Language:English
Subjects:
Biopsy
Brief Report
Case reports
Cells
Child
Cysts
Female
Humans
Lesions
Literature reviews
Mandibular Neoplasms - pathology
Mandibular Neoplasms - surgery
Maxillofacial
Maxillofacial surgery
Medical imaging
Medicine
Medicine & Public Health
Odontogenic tumors
Odontogenic Tumors - diagnosis
Odontogenic Tumors - pathology
Pathology
Tumors
Citations: Items that this one cites
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Summary:Dentinogenic ghost cell tumors are rare tumors, and few cases of them were reported in the literature. The presence of pigment in odontogenic lesions is a rare unexplained histological finding. In this report, we describe a unique case of a 7-year-old girl that was referred to the Department of Oral and Maxillofacial Surgery complaining of a left mandibular swelling. Clinical examination revealed a huge, ulcerated mass. Both incisional and excisional biopsies revealed a benign infiltrative odontogenic tumor with admixed ameloblast-like cells and pigmented ghost cells, consistent with a pigmented dentinogenic ghost cell tumor. To the best of our knowledge, this is the youngest case of intraosseous dentinogenic ghost cell tumor reported in the English literature and the second report of a pigmented variant. This rare variant should be included in the differential of pigmented odontogenic lesions to avoid misinterpretation, especially in small biopsies.
ISSN:0945-6317
1432-2307
DOI:10.1007/s00428-024-03749-0