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High serum uric acid is a risk factor for arterial stiffness in a Chinese hypertensive population: a cohort study

The prospective cohort study was to explore the association between serum uric acid (SUA) and arterial stiffness in a Chinese hypertensive population. A total of 7444 participants with hypertension who completed two or more measurements of brachial-ankle pulse wave velocity (baPWV) and baseline SUA...

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Published in:Hypertension research 2024-06, Vol.47 (6), p.1512
Main Authors: An, Lina, Wang, Yujing, Liu, Lizhen, Miao, Congliang, Xu, Lina, Wang, Guokun, Zhu, Desheng, Wu, Shouling, Hong, Jiang
Format: Article
Language:English
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Summary:The prospective cohort study was to explore the association between serum uric acid (SUA) and arterial stiffness in a Chinese hypertensive population. A total of 7444 participants with hypertension who completed two or more measurements of brachial-ankle pulse wave velocity (baPWV) and baseline SUA detection were followed-up in the Kailuan Study from 2010 to 2020. A restricted cubic spline curve was used to verify whether there was a linear association between baseline SUA and arterial stiffness. A Cox proportional hazard regression model was used to explore the association of between baseline SUA and the incidence of arterial stiffness. Our results showed that the restricted cubic spline curve revealed a linear relationship between baseline SUA and arterial stiffness in total participants (p 
ISSN:0916-9636
1348-4214
1348-4214
DOI:10.1038/s41440-024-01591-0