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Serum ferritin level is associated with liver fibrosis and incident liver-related outcomes independent of HFE genotype in the general population
Hyperferritinemia reflects iron accumulation in the body and has been associated with metabolic disturbances and alcohol use, and is also a common finding in individuals diagnosed with liver disease. The major genetic regulator of iron metabolism is the gene. The aim of this this study was to invest...
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| Published in: | Scandinavian journal of gastroenterology 2024-05, Vol.59 (5), p.592-599 |
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| container_end_page | 599 |
| container_issue | 5 |
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| container_title | Scandinavian journal of gastroenterology |
| container_volume | 59 |
| creator | Männistö, Ville T Hakkarainen, Konsta Jula, Antti Lundqvist, Annamari Vihervaara, Terhi Erlund, Iris Åberg, Fredrik |
| description | Hyperferritinemia reflects iron accumulation in the body and has been associated with metabolic disturbances and alcohol use, and is also a common finding in individuals diagnosed with liver disease. The major genetic regulator of iron metabolism is the
gene.
The aim of this this study was to investigate the association between serum ferritin and liver fibrosis using the enhanced liver fibrosis (ELF) test, and the association between ferritin and liver-related outcomes in a Finnish population-based cohort of 6194 individuals (45% male, mean [± standard deviation] age, 52.9 ± 14.9 years; body mass index 26.9 ± 4.7 kg/m
). The effects of
variants on these associations were also evaluated.
Serum ferritin levels were significantly associated with liver fibrosis, as estimated by enhanced liver fibrosis (ELF) test in weighted linear regression analysis. Serum ferritin was significantly associated with both all liver-related outcomes (
= 92) and severe liver-related outcomes (
= 54) in weighted Cox regression analysis (hazard ratio [HR] per 1 SD, 1.11 [95% confidence interval (CI) 1.02-1.21];
= 0.012 and HR 1.11 [95% CI 1.02-1.21];
= 0.013, respectively). However, there was association neither between
risk variants and ELF test nor between
risk variants and liver-related outcomes.
Serum ferritin levels were associated with liver fibrosis and incident liver disease, independent of
genotype in the general population. Furthermore, data demonstrated that metabolic disturbances and alcohol use were major risk factors for hyperferritinemia. |
| doi_str_mv | 10.1080/00365521.2024.2314707 |
| format | article |
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gene.
The aim of this this study was to investigate the association between serum ferritin and liver fibrosis using the enhanced liver fibrosis (ELF) test, and the association between ferritin and liver-related outcomes in a Finnish population-based cohort of 6194 individuals (45% male, mean [± standard deviation] age, 52.9 ± 14.9 years; body mass index 26.9 ± 4.7 kg/m
). The effects of
variants on these associations were also evaluated.
Serum ferritin levels were significantly associated with liver fibrosis, as estimated by enhanced liver fibrosis (ELF) test in weighted linear regression analysis. Serum ferritin was significantly associated with both all liver-related outcomes (
= 92) and severe liver-related outcomes (
= 54) in weighted Cox regression analysis (hazard ratio [HR] per 1 SD, 1.11 [95% confidence interval (CI) 1.02-1.21];
= 0.012 and HR 1.11 [95% CI 1.02-1.21];
= 0.013, respectively). However, there was association neither between
risk variants and ELF test nor between
risk variants and liver-related outcomes.
Serum ferritin levels were associated with liver fibrosis and incident liver disease, independent of
genotype in the general population. Furthermore, data demonstrated that metabolic disturbances and alcohol use were major risk factors for hyperferritinemia.</description><identifier>ISSN: 0036-5521</identifier><identifier>ISSN: 1502-7708</identifier><identifier>EISSN: 1502-7708</identifier><identifier>DOI: 10.1080/00365521.2024.2314707</identifier><identifier>PMID: 38329447</identifier><language>eng</language><publisher>England</publisher><subject>Adult ; Aged ; Female ; Ferritins - blood ; Finland - epidemiology ; Genotype ; Hemochromatosis Protein - genetics ; Humans ; Hyperferritinemia - blood ; Hyperferritinemia - genetics ; Linear Models ; Liver Cirrhosis - blood ; Liver Cirrhosis - genetics ; Male ; Middle Aged ; Proportional Hazards Models ; Risk Factors</subject><ispartof>Scandinavian journal of gastroenterology, 2024-05, Vol.59 (5), p.592-599</ispartof><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c257t-68b9fb8ec26a07530979725ca23986616cc811765afd636ec79a5a6376181b8a3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38329447$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Männistö, Ville T</creatorcontrib><creatorcontrib>Hakkarainen, Konsta</creatorcontrib><creatorcontrib>Jula, Antti</creatorcontrib><creatorcontrib>Lundqvist, Annamari</creatorcontrib><creatorcontrib>Vihervaara, Terhi</creatorcontrib><creatorcontrib>Erlund, Iris</creatorcontrib><creatorcontrib>Åberg, Fredrik</creatorcontrib><title>Serum ferritin level is associated with liver fibrosis and incident liver-related outcomes independent of HFE genotype in the general population</title><title>Scandinavian journal of gastroenterology</title><addtitle>Scand J Gastroenterol</addtitle><description>Hyperferritinemia reflects iron accumulation in the body and has been associated with metabolic disturbances and alcohol use, and is also a common finding in individuals diagnosed with liver disease. The major genetic regulator of iron metabolism is the
gene.
The aim of this this study was to investigate the association between serum ferritin and liver fibrosis using the enhanced liver fibrosis (ELF) test, and the association between ferritin and liver-related outcomes in a Finnish population-based cohort of 6194 individuals (45% male, mean [± standard deviation] age, 52.9 ± 14.9 years; body mass index 26.9 ± 4.7 kg/m
). The effects of
variants on these associations were also evaluated.
Serum ferritin levels were significantly associated with liver fibrosis, as estimated by enhanced liver fibrosis (ELF) test in weighted linear regression analysis. Serum ferritin was significantly associated with both all liver-related outcomes (
= 92) and severe liver-related outcomes (
= 54) in weighted Cox regression analysis (hazard ratio [HR] per 1 SD, 1.11 [95% confidence interval (CI) 1.02-1.21];
= 0.012 and HR 1.11 [95% CI 1.02-1.21];
= 0.013, respectively). However, there was association neither between
risk variants and ELF test nor between
risk variants and liver-related outcomes.
Serum ferritin levels were associated with liver fibrosis and incident liver disease, independent of
genotype in the general population. Furthermore, data demonstrated that metabolic disturbances and alcohol use were major risk factors for hyperferritinemia.</description><subject>Adult</subject><subject>Aged</subject><subject>Female</subject><subject>Ferritins - blood</subject><subject>Finland - epidemiology</subject><subject>Genotype</subject><subject>Hemochromatosis Protein - genetics</subject><subject>Humans</subject><subject>Hyperferritinemia - blood</subject><subject>Hyperferritinemia - genetics</subject><subject>Linear Models</subject><subject>Liver Cirrhosis - blood</subject><subject>Liver Cirrhosis - genetics</subject><subject>Male</subject><subject>Middle Aged</subject><subject>Proportional Hazards Models</subject><subject>Risk Factors</subject><issn>0036-5521</issn><issn>1502-7708</issn><issn>1502-7708</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNo9kUtLxDAUhYMoOj5-gpKlm455NI8uRRwVBBfquqTprUbapiapMv_Cn2w7M7q6hPOdc7k5CJ1TsqREkytCuBSC0SUjLF8yTnNF1B5aUEFYphTR-2gxM9kMHaHjGD8IIULlxSE64pqzIs_VAv08Qxg73EAILrket_AFLXYRmxi9dSZBjb9deset-4KAG1cFH2e5r7HrrauhT1stC9BucD8m6zuIk17DAP0G8Q2-X93iN-h9Wg8waTi9w_yGYFo8-GGc3M73p-igMW2Es908Qa-r25eb--zx6e7h5voxs0yolEldFU2lwTJpiBKcFKpQTFjDeKGlpNJaTamSwjS15BKsKowwkitJNa204Sfocps7BP85Qkxl56KFtjU9-DGWrJiS6BShJ1RsUTvdHgM05RBcZ8K6pKScyyj_yijnMspdGZPvYrdirDqo_11_v89_Af-ehsI</recordid><startdate>20240503</startdate><enddate>20240503</enddate><creator>Männistö, Ville T</creator><creator>Hakkarainen, Konsta</creator><creator>Jula, Antti</creator><creator>Lundqvist, Annamari</creator><creator>Vihervaara, Terhi</creator><creator>Erlund, Iris</creator><creator>Åberg, Fredrik</creator><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>20240503</creationdate><title>Serum ferritin level is associated with liver fibrosis and incident liver-related outcomes independent of HFE genotype in the general population</title><author>Männistö, Ville T ; Hakkarainen, Konsta ; Jula, Antti ; Lundqvist, Annamari ; Vihervaara, Terhi ; Erlund, Iris ; Åberg, Fredrik</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c257t-68b9fb8ec26a07530979725ca23986616cc811765afd636ec79a5a6376181b8a3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Adult</topic><topic>Aged</topic><topic>Female</topic><topic>Ferritins - blood</topic><topic>Finland - epidemiology</topic><topic>Genotype</topic><topic>Hemochromatosis Protein - genetics</topic><topic>Humans</topic><topic>Hyperferritinemia - blood</topic><topic>Hyperferritinemia - genetics</topic><topic>Linear Models</topic><topic>Liver Cirrhosis - blood</topic><topic>Liver Cirrhosis - genetics</topic><topic>Male</topic><topic>Middle Aged</topic><topic>Proportional Hazards Models</topic><topic>Risk Factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Männistö, Ville T</creatorcontrib><creatorcontrib>Hakkarainen, Konsta</creatorcontrib><creatorcontrib>Jula, Antti</creatorcontrib><creatorcontrib>Lundqvist, Annamari</creatorcontrib><creatorcontrib>Vihervaara, Terhi</creatorcontrib><creatorcontrib>Erlund, Iris</creatorcontrib><creatorcontrib>Åberg, Fredrik</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Scandinavian journal of gastroenterology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Männistö, Ville T</au><au>Hakkarainen, Konsta</au><au>Jula, Antti</au><au>Lundqvist, Annamari</au><au>Vihervaara, Terhi</au><au>Erlund, Iris</au><au>Åberg, Fredrik</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Serum ferritin level is associated with liver fibrosis and incident liver-related outcomes independent of HFE genotype in the general population</atitle><jtitle>Scandinavian journal of gastroenterology</jtitle><addtitle>Scand J Gastroenterol</addtitle><date>2024-05-03</date><risdate>2024</risdate><volume>59</volume><issue>5</issue><spage>592</spage><epage>599</epage><pages>592-599</pages><issn>0036-5521</issn><issn>1502-7708</issn><eissn>1502-7708</eissn><abstract>Hyperferritinemia reflects iron accumulation in the body and has been associated with metabolic disturbances and alcohol use, and is also a common finding in individuals diagnosed with liver disease. The major genetic regulator of iron metabolism is the
gene.
The aim of this this study was to investigate the association between serum ferritin and liver fibrosis using the enhanced liver fibrosis (ELF) test, and the association between ferritin and liver-related outcomes in a Finnish population-based cohort of 6194 individuals (45% male, mean [± standard deviation] age, 52.9 ± 14.9 years; body mass index 26.9 ± 4.7 kg/m
). The effects of
variants on these associations were also evaluated.
Serum ferritin levels were significantly associated with liver fibrosis, as estimated by enhanced liver fibrosis (ELF) test in weighted linear regression analysis. Serum ferritin was significantly associated with both all liver-related outcomes (
= 92) and severe liver-related outcomes (
= 54) in weighted Cox regression analysis (hazard ratio [HR] per 1 SD, 1.11 [95% confidence interval (CI) 1.02-1.21];
= 0.012 and HR 1.11 [95% CI 1.02-1.21];
= 0.013, respectively). However, there was association neither between
risk variants and ELF test nor between
risk variants and liver-related outcomes.
Serum ferritin levels were associated with liver fibrosis and incident liver disease, independent of
genotype in the general population. Furthermore, data demonstrated that metabolic disturbances and alcohol use were major risk factors for hyperferritinemia.</abstract><cop>England</cop><pmid>38329447</pmid><doi>10.1080/00365521.2024.2314707</doi><tpages>8</tpages></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0036-5521 |
| ispartof | Scandinavian journal of gastroenterology, 2024-05, Vol.59 (5), p.592-599 |
| issn | 0036-5521 1502-7708 1502-7708 |
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| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Adult Aged Female Ferritins - blood Finland - epidemiology Genotype Hemochromatosis Protein - genetics Humans Hyperferritinemia - blood Hyperferritinemia - genetics Linear Models Liver Cirrhosis - blood Liver Cirrhosis - genetics Male Middle Aged Proportional Hazards Models Risk Factors |
| title | Serum ferritin level is associated with liver fibrosis and incident liver-related outcomes independent of HFE genotype in the general population |
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