The role of high mobility group AT-hook 1 in viral infections: Implications for cancer pathogenesis

• Published in: The international journal of biochemistry & cell biology 2024-04, Vol.169, p.106532-106532, Article 106532
• Main Authors: Akade, Esma’il, Jalilian, Shahram
• Format: Article
• Language: English
• Subjects: beta Catenin - metabolism; Carcinogenesis; HMGA1a Protein - genetics; HMGA1a Protein - metabolism; HMGY; Humans; Innate immunity; Neoplasms - genetics; Oncoviruses; Phosphatidylinositol 3-Kinases; Proto-Oncogene Proteins c-akt; Transcription Factors; Tumorigenesis; Virus Diseases
• ISSN: 1357-2725; 1878-5875
• DOI: 10.1016/j.biocel.2024.106532

The crucial role of high mobility group AT-hook 1 (HMGA1) proteins in nuclear processes such as gene transcription, DNA replication, and chromatin remodeling is undeniable. Elevated levels of HMGA1 have been associated with unfavorable clinical outcomes and adverse differentiation status across various cancer types. HMGA1 regulates a diverse array of biological pathways, including tumor necrosis factor-alpha/nuclear factor-kappa B (TNF‐α/NF‐κB), epidermal growth factor receptor (EGFR), Hippo, Rat sarcoma/extracellular signal-regulated kinase (Ras/ERK), protein kinase B (Akt), wingless-related integration site/beta-catenin (Wnt/beta‐catenin), and phosphoinositide 3-kinase/protein kinase B (PI3‐K/Akt). While researchers have extensively investigated tumors in the reproductive, digestive, urinary, and hematopoietic systems, mounting evidence suggests that HMGA1 plays a critical role as a tumorigenic factor in tumors across all functional systems. Given its broad interaction network, HMGA1 is an attractive target for viral manipulation. Some viruses, including herpes simplex virus type 1, human herpesvirus 8, human papillomavirus, JC virus, hepatitis B virus, human immunodeficiency virus type 1, severe acute respiratory syndrome Coronavirus 2, and influenza viruses, utilize HMGA1 influence for infection. This interaction, particularly in oncogenesis, is crucial. Apart from the direct oncogenic effect of some of the mentioned viruses, the hit-and-run theory postulates that viruses can instigate cancer even before being completely eradicated from the host cell, implying a potentially greater impact of viruses on cancer development than previously assumed. This review explores the interplay between HMGA1, viruses, and host cellular machinery, aiming to contribute to a deeper understanding of viral-induced oncogenesis, paving the way for innovative strategies in cancer research and treatment.