Association between ASL MRI-derived cerebral blood flow and outcomes after pediatric cardiac arrest

• Published in: Resuscitation 2024-03, Vol.196, p.110128, Article 110128
• Main Authors: Kirschen, Matthew P, Ouyang, Minhui, Patel, Bhavesh, Berman, Jeffrey I, Burnett, Ryan, Berg, Robert A, Diaz-Arrastia, Ramon, Topjian, Alexis, Huang, Hao, Vossough, Arastoo
• Format: Article
• Language: English
• Subjects: Arterial spin labeling; Brain - diagnostic imaging; Cerebrovascular Circulation - physiology; Child; Child, Preschool; Female; Heart Arrest - therapy; Humans; Magnetic Resonance Imaging - methods; Male; MRI; Neuroimaging; Pediatric cardiac arrest; Spin Labels
• ISSN: 0300-9572; 1873-1570; 1873-1570
• DOI: 10.1016/j.resuscitation.2024.110128

Cerebral blood flow (CBF) is dysregulated after cardiac arrest. It is unknown if post-arrest CBF is associated with outcome. We aimed to determine the association of CBF derived from arterial spin labelling (ASL) MRI with outcome after pediatric cardiac arrest. Retrospective observational study of patients ≤18 years who had a clinically obtained brain MRI within 7 days of cardiac arrest between June 2005 and December 2019. Primary outcome was unfavorable neurologic status: change in Pediatric Cerebral Performance Category (PCPC) ≥1 from pre-arrest that resulted in hospital discharge PCPC 3–6. We measured CBF in whole brain and regions of interest (ROIs) including frontal, parietal, and temporal cortex, caudate, putamen, thalamus, and brainstem using pulsed ASL. We compared CBF between outcome groups using Wilcoxon Rank-Sum and performed logistic regression to associate each region’s CBF with outcome, accounting for age, sex, and time between arrest and MRI. Forty-eight patients were analyzed (median age 2.8 [IQR 0.95, 8.8] years, 65% male). Sixty-nine percent had unfavorable outcome. Time from arrest to MRI was 4 [3,5] days and similar between outcome groups (p = 0.39). Whole brain median CBF was greater for unfavorable compared to favorable groups (28.3 [20.9,33.0] vs. 19.6 [15.3,23.1] ml/100 g/min, p = 0.007), as was CBF in individual ROIs. Greater CBF in the whole brain and individual ROIs was associated with higher odds of unfavorable outcome after controlling for age, sex, and days from arrest to MRI (aOR for whole brain 19.08 [95% CI 1.94, 187.41]). CBF measured 3–5 days after pediatric cardiac arrest by ASL MRI was independently associated with unfavorable outcome.