Alactic base excess (ABE): a novel internal milieu parameter—its concept and clinical importance

Inspired by the Stewart-Figge acid–base approach, Gattinoni et al. recently introduced a new internal milieu parameter known as alactic base excess (ABE). The authors defined ABE as the sum of lactate and standard base excess. In the context of sepsis, ABE has been proposed as a valuable marker to d...

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Bibliographic Details
Published in:International urology and nephrology 2024-06, Vol.56 (6), p.1983-1986
Main Authors: Hoque, Md, Nagourney, Jason, Pawlowski, Thomas, Cantos, Joaquin, Aroca-Martinez, Gustavo, Huespe, Ivan, Musso, Carlos G.
Format: Article
Language:English
Subjects:
Acid-Base Equilibrium
Acid-Base Imbalance
Acidosis
Acidosis - diagnosis
Biomarkers - blood
Clinical Relevance
Humans
Lactic acid
Lactic Acid - blood
Medicine
Medicine & Public Health
Metabolic acidosis
Nephrology
Nephrology - Review
Patients
Prognosis
Renal failure
Renal function
Sepsis
Urology
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Summary:Inspired by the Stewart-Figge acid–base approach, Gattinoni et al. recently introduced a new internal milieu parameter known as alactic base excess (ABE). The authors defined ABE as the sum of lactate and standard base excess. In the context of sepsis, ABE has been proposed as a valuable marker to discern between metabolic acidosis resulting from the accumulation of lactate and the retention of fixed acids, which can occur in cases of renal failure. Multiple studies have demonstrated that a negative ABE value (
ISSN:1573-2584
0301-1623
1573-2584
DOI:10.1007/s11255-024-03949-2