Modulation of Acute Intestinal Inflammation by Dandelion Polysaccharides: An In-Depth Analysis of Antioxidative, Anti-Inflammatory Effects and Gut Microbiota Regulation

Acute colitis is a complex disease that can lead to dysregulation of the gut flora, inducing more complex parenteral diseases. Dandelion polysaccharides (DPSs) may have potential preventive and therapeutic effects on enteritis. In this study, LPS was used to induce enteritis and VC was used as a pos...

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Published in:International journal of molecular sciences 2024-02, Vol.25 (3), p.1429
Main Authors: Li, Zhu, Li, Xinyao, Shi, Panpan, Li, Pingping, Fu, Yue, Tan, Guifeng, Zhou, Junjuan, Zeng, Jianguo, Huang, Peng
Format: Article
Language:English
Subjects:
Anti-inflammatory drugs
Antioxidants
Bacteria
Biodiversity
Blood
Calibration
Colitis
Drug dosages
Health aspects
Inflammation
Medicine
Microbiota
Microbiota (Symbiotic organisms)
Molecular weight
Polysaccharides
Small intestine
Tumor necrosis factor
Vitamin C
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Summary:Acute colitis is a complex disease that can lead to dysregulation of the gut flora, inducing more complex parenteral diseases. Dandelion polysaccharides (DPSs) may have potential preventive and therapeutic effects on enteritis. In this study, LPS was used to induce enteritis and VC was used as a positive drug control to explore the preventive and therapeutic effects of DPS on enteritis. The results showed that DPS could repair the intestinal barrier, down-regulate the expression of TNF-α, IL-6, IL-1β, and other pro-inflammatory factors, up-regulate the expression of IL-22 anti-inflammatory factor, improve the antioxidant capacity of the body, and improve the structure of intestinal flora. It is proved that DPS can effectively prevent and treat LPS-induced acute enteritis and play a positive role in promoting intestinal health.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25031429