Neuropsychological profiles comparison between Multiple Sclerosis patients and Multiple Sclerosis patients with overlapping features of Systemic Lupus Erythematosus

Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE) are autoimmune disorders that may lead to cognitive impairment. This study aimed to compare the neuropsychological profiles of patients with MS, and MS and coexisting SLE features. We included a total of 90 participants, divided into 3 g...

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Bibliographic Details
Published in:Journal of neuroimmunology 2024-02, Vol.387, p.578270-578270, Article 578270
Main Authors: Stavrogianni, Konstantina, Kitsos, Dimitrios K., Giannopapas, Vasileios, Chasiotis, Athanasios K., Christouli, Niki, Paraskevas, Panagiotis G., Zompola, Christina, Tsivgoulis, Georgios, Paraskevas, George P., Giannopoulos, Sotirios
Format: Article
Language:English
Subjects:
Cognition Disorders
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - etiology
Humans
Lupus Erythematosus, Systemic - complications
Memory
Multiple sclerosis (MS)
Multiple Sclerosis - complications
Multiple Sclerosis, Relapsing-Remitting - pathology
Neuropsychological profiles
Neuropsychological Tests
Processing speed
Systemic lupus erythematosus (SLE) features
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Summary:Multiple sclerosis (MS) and Systemic Lupus Erythematosus (SLE) are autoimmune disorders that may lead to cognitive impairment. This study aimed to compare the neuropsychological profiles of patients with MS, and MS and coexisting SLE features. We included a total of 90 participants, divided into 3 groups: 30 patients with clinically definite relapsing remitting MS, 30 with coexisting MS and incomplete SLE (overlap group) and 30 healthy controls (HC). All participants underwent neuropsychological assessment with the Montreal Cognitive Assessment (MoCA), Symbol Digit Modalities Test (SDMT), Paced Auditory Serial Addition Test (PASAT), and Selective Reminding Test (SRT). Both groups scored lower on the MoCA compared to the HC (p 
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2023.578270