Altered Levels of Natural Autoantibodies against Heat Shock Proteins in Pregnant Women with Hashimoto's Thyroiditis

The function of natural autoantibodies (nAAbs) in maintaining immunological tolerance has been comprehensively explained; however, their function in pregnant patients dealing with autoimmune diseases has not been thoroughly investigated. As Hashimoto's thyroiditis (HT) is the predominant organ-...

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Bibliographic Details
Published in:International journal of molecular sciences 2024-02, Vol.25 (3), p.1423
Main Authors: Simon, Diána, Erdő-Bonyár, Szabina, Böröcz, Katalin, Balázs, Noémi, Badawy, Ahmed, Bajnok, Anna, Nörenberg, Jasper, Serény-Litvai, Tímea, Várnagy, Ákos, Kovács, Kálmán, Hantosi, Eszter, Mezősi, Emese, Németh, Péter, Berki, Tímea
Format: Article
Language:English
Subjects:
Antibodies
Antigens
Autoantibodies
Autoimmune diseases
Autoimmunity
B cells
Enzymes
Health aspects
Heat shock proteins
Immune system
Immunoglobulin G
Immunology
Investigations
Medical research
Medicine, Experimental
Pregnancy
Pregnant women
Ratios
Thyroiditis
Vaccines
Women
Womens health
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Summary:The function of natural autoantibodies (nAAbs) in maintaining immunological tolerance has been comprehensively explained; however, their function in pregnant patients dealing with autoimmune diseases has not been thoroughly investigated. As Hashimoto's thyroiditis (HT) is the predominant organ-specific autoimmune condition of women of childbearing age, this study's objective was to evaluate IgM and IgG nAAbs targeting mitochondrial citrate synthase (CS) and heat shock proteins (Hsp60 and Hsp70) in women diagnosed with HT who were pregnant (HTP). Serum samples collected from HTP and healthy pregnant (HP) women in the first and third trimesters were tested using in-house-developed enzyme-linked immunosorbent assays (ELISAs). Our findings indicate the stability of nAAbs against CS and Hsps throughout the pregnancies of both healthy women and those with HT. However, during both trimesters, HTP patients displayed elevated levels of IgM isotype nAAbs against Hsp60 and Hsp70 compared to HP women, suggesting a regulatory role of IgM nAAbs during the pregnancies of patients with HT. Nonetheless, levels of IgG isotype nAAbs against Hsps were lower solely in the third trimester among HTP patients, resulting in a higher IgM/IgG ratio, which indicates their importance in alterations of the nAAb network during pregnancy in patients with HT.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms25031423