Urinary metabolite biomarkers of pregnancy complications associated with maternal exposure to particulate matter

Particulate matter 2.5 (PM2.5) is associated with reproductive health and adverse pregnancy outcomes. However, studies evaluating biological markers of PM2.5 are lacking, and identifying biomarkers for estimating prenatal exposure to prevent pregnancy complications is essential. Therefore, we aimed...

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Published in:Reproductive toxicology (Elmsford, N.Y.) N.Y.), 2024-03, Vol.124, p.108550, Article 108550
Main Authors: Park, Sunwha, Shim, Minki, Lee, Gain, You, Young-Ah, Kim, Soo Min, Hur, Young Min, Ko, Hyejin, Park, Mi Hye, Na, Sung Hun, Kim, Young-Han, Cho, Geum Joon, Bae, Jin-Gon, Lee, Soo-Jeong, Lee, Sun Hwa, Lee, Dong-Kyu, Kim, Young Ju
Format: Article
Language:English
Subjects:
Air Pollutants - analysis
Air Pollution - adverse effects
Arabinose
Arabinose - analysis
Case-Control Studies
Cohort Studies
Diabetes, Gestational
Female
Gestational diabetes
Humans
Infant, Newborn
Maternal Exposure - adverse effects
Particulate matter
Particulate Matter - analysis
Pregnancy
Premature Birth
Preterm birth
Ribose
Ribose - analysis
Xylose
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Summary:Particulate matter 2.5 (PM2.5) is associated with reproductive health and adverse pregnancy outcomes. However, studies evaluating biological markers of PM2.5 are lacking, and identifying biomarkers for estimating prenatal exposure to prevent pregnancy complications is essential. Therefore, we aimed to explore urine metabolites that are easy to measure as biomarkers of exposure. In this matched case-control study based on the PM2.5 exposure, 30 high PM2.5 group (>15 μg/m3) and 30 low PM2.5 group (
ISSN:0890-6238
1873-1708
1873-1708
DOI:10.1016/j.reprotox.2024.108550