Quality of life, mood disorders, and cognitive impairment in adults with β-thalassemia

Advances in understanding the disease process in β-thalassemia supported development of various treatment strategies that resulted in improved survival. Improved survival, however, allowed multiple morbidities to manifest and cemented the need for frequent, lifelong treatment. This has directly impa...

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Bibliographic Details
Published in:Blood reviews 2024-05, Vol.65, p.101181-101181, Article 101181
Main Authors: Bizri, Maya, Koleilat, Rawan, Akiki, Nathalie, Dergham, Reem, Mihailescu, Alexandra Monica, Bou-Fakhredin, Rayan, Musallam, Khaled M., Taher, Ali T.
Format: Article
Language:English
Subjects:
Adult
Anxiety
beta-Thalassemia - complications
beta-Thalassemia - therapy
Cognition
Cognitive Dysfunction - etiology
Depression
Humans
Mood Disorders - etiology
Psychiatry
QoL
Quality of Life - psychology
Suicide
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Summary:Advances in understanding the disease process in β-thalassemia supported development of various treatment strategies that resulted in improved survival. Improved survival, however, allowed multiple morbidities to manifest and cemented the need for frequent, lifelong treatment. This has directly impacted patients' health-related quality of life and opened the door for various psychiatric and cognitive disorders to potentially develop. In this review, we summarize available evidence on quality of life, depression and anxiety, suicidality, and cognitive impairment in adult patients with β-thalassemia while sharing our personal insights from experience in treating patients with both transfusion-dependent and non-transfusion-dependent forms.
ISSN:0268-960X
1532-1681
DOI:10.1016/j.blre.2024.101181