Expression levels of ADAMTS 5, 9, and 12 in endometrial polyps and their predictive value for the diagnosis and recurrence of endometrial polyps

•This study identified higher serologic levels of ADAMTS12 in patients with Eps.•The study identified ADAMTS12 as a useful biological marker for predicting the occurrence and their recurrence of EPs.•It may provide new ideas for the subsequent development of drugs to treat EPs and prevent their recu...

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Bibliographic Details
Published in:European journal of obstetrics & gynecology and reproductive biology 2024-04, Vol.295, p.86-91
Main Authors: Nian, Jiejie, Zhu, Yuqing, Lv, Xiaoli, Zhang, Yue, Xue, Zhongkai, Wu, Zhongran, Zhou, Yujia, Liu, Yu
Format: Article
Language:English
Subjects:
ADAMTS proteases
Endometrial polyps
Endometriotic diseases
Extracellular matrix
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Summary:•This study identified higher serologic levels of ADAMTS12 in patients with Eps.•The study identified ADAMTS12 as a useful biological marker for predicting the occurrence and their recurrence of EPs.•It may provide new ideas for the subsequent development of drugs to treat EPs and prevent their recurrence. Endometrial polyps (EPs) are common gynecological disorders for which no clear etiology has been found. ADAMTS have been associated with a variety of diseases. This study aimed to investigate the potential correlation between serologic levels of ADAMTS 5, 9, and 12 in patients with EPs. A total of 88 patients were categorized into two groups: the EPs group, consisting of recurrent EPs and first occurrence EPs, and a control group. The study compared the general information and serum levels of ADAMTS 5, 9, and 12 between the groups. Regarding the general data, a statistically significant age difference (p 
ISSN:0301-2115
1872-7654
DOI:10.1016/j.ejogrb.2024.02.008