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Endoscopic Complications Are More Frequent in Levodopa-Carbidopa Intestinal Gel Treatment via JET-PEG in Parkinson's Disease Patients Compared to Nutritional PEG in Non-Parkinson's Disease Patients

: To date, no studies comparing complication rates between patients with nutritional percutaneous endoscopic gastrostomy (N-PEG) and Parkinson's disease (PD) patients with percutaneous endoscopic gastro-jejunostomy (JET-PEG) for treatment administration have been published. Our study aimed to c...

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Published in:Journal of clinical medicine 2024-01, Vol.13 (3), p.703
Main Authors: Gombošová, Laura, Deptová, Jana, Jochmanová, Ivana, Svoreňová, Tatiana, Veseliny, Eduard, Zakuciová, Mária, Haň, Vladimír, Lacková, Alexandra, Kulcsárová, Kristína, Ostrožovičová, Miriama, Ventosa, Joaquim Ribeiro, Trcková, Lenka, Lazúrová, Ivica, Škorvánek, Matej
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Language:English
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Summary:: To date, no studies comparing complication rates between patients with nutritional percutaneous endoscopic gastrostomy (N-PEG) and Parkinson's disease (PD) patients with percutaneous endoscopic gastro-jejunostomy (JET-PEG) for treatment administration have been published. Our study aimed to compare complication rates and the number of re-endoscopies between N-PEG and JET-PEG patients. : Individuals requiring N-PEG or JET-PEG insertion between 2014 and 2021 were included in this single-center retrospective observational study. Complications were divided into time-related medical and technical complications. Reasons for post-insertion re-endoscopies and their number were also analyzed. : Eighty-seven subjects, 47 (54.02%) in JET-PEG group and 40 (45.98%) in the N-PEG group, were included. Early and technical complications were more frequent in JET-PEG vs. N-PEG subjects (70% vs. 10% [ < 0.001], and 54.5% vs. 5.1% [ < 0.001], respectively). The presence of psychiatric disease was associated with a higher number of early complications ( < 0.002). All three types of complications were significantly more frequent in subjects where a healthcare professional did not handle PEG ( < 0.001). Subjects with JET-PEG required a higher number of re-endoscopies compared to the N-PEG group (57.1% vs. 35%, = 0.05). : Complications are significantly more common in individuals with JET-PEG than those with N-PEG, which can be attributed to higher mobility in PD patients.
ISSN:2077-0383
2077-0383
DOI:10.3390/jcm13030703