The Antiobesity Effects of Rosehip (Rosa canina) Flesh by Antagonizing the PPAR Gamma Activity in High‐Fat Diet‐Fed Mice

• Published in: Molecular nutrition & food research 2024-03, Vol.68 (5), p.e2300539-n/a
• Main Authors: Sanz‐Lamora, Hèctor, Nicola‐Llorente, Mariano, Torres‐Oteros, Daniel, Pérez‐Martí, Albert, Aghziel, Inass, Lozano‐Castellón, Julián, Vallverdú‐Queralt, Anna, Canudas, Sílvia, Marrero, Pedro F., Haro, Diego, Relat, Joana
• Format: Article
• Language: English
• Subjects: Adipocytes; Adipose tissue; Animal models; Animals; Anti-Obesity Agents - metabolism; Anti-Obesity Agents - pharmacology; Body weight gain; cell signaling; Diabetes mellitus; Diet; Diet, High-Fat - adverse effects; Dietary supplements; Gene expression; Gene regulation; Glucose metabolism; High fat diet; Hyperglycemia; Insulin resistance; lipid metabolism; Lipids; Lipogenesis; Liver - metabolism; Mice; Mice, Inbred C57BL; Molecular modelling; Obesity; Obesity - etiology; Oxidation; Peroxisome proliferator-activated receptors; Plant Extracts - metabolism; Plant Extracts - pharmacology; PPAR gamma - metabolism; Rosa - metabolism; Rosa canina; weight management
• ISSN: 1613-4125; 1613-4133
• DOI: 10.1002/mnfr.202300539

Scope The rosehip (Rosa canina) is a perennial shrub with a reddish pseudofruit that has demonstrated antidiabetic, antiatherosclerotic, and antiobesogenic effects in rodent models but there is low information about the molecular mechanisms underlying these effects on the onset and progression of diet‐induced obesity. Methods and results Four‐week‐old C57BL/6J male mice are subjected to a high‐fat diet (HFD)‐supplemented or not with R. canina flesh for 18 weeks. The results indicated that the R. canina flesh exerts a preventive effect on HFD‐induced obesity with a significant reduction in body‐weight gain and an improvement of hyperglycemia and insulin resistance caused by a HFD. At the tissue level, subcutaneous white adipose tissue exhibits a higher number of smaller adipocytes, with decreased lipogenesis. On its side, the liver shows a significant decrease in lipid droplet content and in the expression of genes related to lipogenesis, fatty acid oxidation, and glucose metabolism. Finally, the data suggest that most of these effects agree with the presence of a putative Perosxisome proliferator‐activated receptor gamma (PPARγ) antagonist in the R. canina flesh. Conclusions R. canina flesh dietary supplementation slows down the steatotic effect of a HFD at least in part through the regulation of the transcriptional activity of PPARγ. R. canina flesh exerts a preventive effect on HFD‐induced obesity with a significant reduction in body weight gain, an improvement of hyperglycemia and insulin resistance, and an amelioration of the hepatic steatosis caused by a HFD. These effects go, at least in part through the regulation of the transcriptional activity of PPARγ.