Screen time in the development of type 2 diabetes mellitus (T2DM) : a two-sample Mendelian randomization study

Objective: This study aimed to investigate the potential causal relationship between screen time and the risk of developing type 2 diabetes mellitus (T2DM) using Mendelian randomization. Methods: Two-sample Mendelian randomization was conducted, utilizing genetic variants associated with different t...

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Bibliographic Details
Published in:Endocrine 2024, Vol.85 (1), p.158-167
Main Authors: Qiu, Zhengqi, Jia, Xueyuan, Li, Yufei, Fu, Yancheng, Xiao, Ying
Format: Article
Language:English
Subjects:
Cellular telephones
Diabetes
Diabetes mellitus (non-insulin dependent)
Endocrinology
Genetic diversity
Humanities and Social Sciences
Internal Medicine
Medicine
Medicine & Public Health
multidisciplinary
Original Article
Science
Screen time
Single-nucleotide polymorphism
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Summary:Objective: This study aimed to investigate the potential causal relationship between screen time and the risk of developing type 2 diabetes mellitus (T2DM) using Mendelian randomization. Methods: Two-sample Mendelian randomization was conducted, utilizing genetic variants associated with different types of screen time as instrumental variables. Single nucleotide polymorphisms (SNPs) were used to assess the primary outcome, which was the risk of developing T2DM. Results: The analysis revealed a significant positive causal association between television viewing time and the risk of T2DM. Specifically, excessive television viewing time was found to increase the risk of developing T2DM (OR: 2.39, 95% CI: 1.90 to 3.00, P  
ISSN:1559-0100
1355-008X
1559-0100
DOI:10.1007/s12020-024-03723-5