Largest comparison between onset and relapses of acquired thrombotic thrombocytopenic purpura reveals severe neurological involvement and worse analytic parameters at debut

It has been proposed that the onset of Acquired Thrombotic Thrombocytopenic Purpura (iTTP) is more severe than subsequent relapses; however, existing studies have limitations. We conducted a retrospective observational study to compare analytical and clinical severity of onset and relapse aTTP cases...

Full description

Saved in:
Bibliographic Details
Published in:Annals of hematology 2024-03, Vol.103 (3), p.725-727
Main Authors: Vegas Villalmanzo, Blanca, Cantera Estefanía, Rodrigo, Muñoz Madrid, Sara, Cerrato Salas, Mariana, Arnaiz Martín, Irene, Molina Pérez, Marta, Sagrista López, Beatriz, Ruiz Ramírez, Yolanda, Cucharero Martín, Javier, Estival Monteliú, Pablo, Ropero Gradilla, Paloma, Ferrer Benito, Sara, Martín Hernández, María Paz, González Fernández, Fernando Ataulfo, Gómez Álvarez, Miguel, Villegas Martínez, Ana, Benavente Cuesta, Celina, Martínez Nieto, Jorge
Format: Article
Language:English
Subjects:
ADAMTS13 Protein
Anemia
Aphasia
Consciousness
Data collection
Diplopia
Hematology
Hemoglobin
Humans
Ischemia
Medicine
Medicine & Public Health
Mortality
Nervous system
Observational studies
Oncology
Purpura
Purpura, Thrombotic Thrombocytopenic - diagnosis
Purpura, Thrombotic Thrombocytopenic - therapy
Recurrence
Retrospective Studies
Statistical analysis
Citations: Items that this one cites
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:It has been proposed that the onset of Acquired Thrombotic Thrombocytopenic Purpura (iTTP) is more severe than subsequent relapses; however, existing studies have limitations. We conducted a retrospective observational study to compare analytical and clinical severity of onset and relapse aTTP cases between 2012 and 2023. A total of 370 episodes of aTTP were analyzed, comprising 272 at initial diagnosis and 98 relapses. At onset, analytical parameters indicative of severity (low hemoglobin, low platelet count, and increased LDH) were significantly worse; patients had severe neurological symptoms ( p
ISSN:0939-5555
1432-0584
1432-0584
DOI:10.1007/s00277-024-05634-x