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Largest comparison between onset and relapses of acquired thrombotic thrombocytopenic purpura reveals severe neurological involvement and worse analytic parameters at debut
It has been proposed that the onset of Acquired Thrombotic Thrombocytopenic Purpura (iTTP) is more severe than subsequent relapses; however, existing studies have limitations. We conducted a retrospective observational study to compare analytical and clinical severity of onset and relapse aTTP cases...
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| Published in: | Annals of hematology 2024-03, Vol.103 (3), p.725-727 |
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| container_title | Annals of hematology |
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| creator | Vegas Villalmanzo, Blanca Cantera Estefanía, Rodrigo Muñoz Madrid, Sara Cerrato Salas, Mariana Arnaiz Martín, Irene Molina Pérez, Marta Sagrista López, Beatriz Ruiz Ramírez, Yolanda Cucharero Martín, Javier Estival Monteliú, Pablo Ropero Gradilla, Paloma Ferrer Benito, Sara Martín Hernández, María Paz González Fernández, Fernando Ataulfo Gómez Álvarez, Miguel Villegas Martínez, Ana Benavente Cuesta, Celina Martínez Nieto, Jorge |
| description | It has been proposed that the onset of Acquired Thrombotic Thrombocytopenic Purpura (iTTP) is more severe than subsequent relapses; however, existing studies have limitations. We conducted a retrospective observational study to compare analytical and clinical severity of onset and relapse aTTP cases between 2012 and 2023. A total of 370 episodes of aTTP were analyzed, comprising 272 at initial diagnosis and 98 relapses. At onset, analytical parameters indicative of severity (low hemoglobin, low platelet count, and increased LDH) were significantly worse; patients had severe neurological symptoms (
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| doi_str_mv | 10.1007/s00277-024-05634-x |
| format | article |
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p
<0.001) and ≥ 3 points in the TMA mortality score (
p
<0.001). In conclusion, the onset of aTTP is associated with worse analytical parameters and severe neurological involvement.</description><identifier>ISSN: 0939-5555</identifier><identifier>ISSN: 1432-0584</identifier><identifier>EISSN: 1432-0584</identifier><identifier>DOI: 10.1007/s00277-024-05634-x</identifier><identifier>PMID: 38279007</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>ADAMTS13 Protein ; Anemia ; Aphasia ; Consciousness ; Data collection ; Diplopia ; Hematology ; Hemoglobin ; Humans ; Ischemia ; Medicine ; Medicine & Public Health ; Mortality ; Nervous system ; Observational studies ; Oncology ; Purpura ; Purpura, Thrombotic Thrombocytopenic - diagnosis ; Purpura, Thrombotic Thrombocytopenic - therapy ; Recurrence ; Retrospective Studies ; Statistical analysis</subject><ispartof>Annals of hematology, 2024-03, Vol.103 (3), p.725-727</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-fc360b1511eea583c72f7a1f0e0636c1c6028c91a5ae6402505dd3880613bca93</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38279007$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Vegas Villalmanzo, Blanca</creatorcontrib><creatorcontrib>Cantera Estefanía, Rodrigo</creatorcontrib><creatorcontrib>Muñoz Madrid, Sara</creatorcontrib><creatorcontrib>Cerrato Salas, Mariana</creatorcontrib><creatorcontrib>Arnaiz Martín, Irene</creatorcontrib><creatorcontrib>Molina Pérez, Marta</creatorcontrib><creatorcontrib>Sagrista López, Beatriz</creatorcontrib><creatorcontrib>Ruiz Ramírez, Yolanda</creatorcontrib><creatorcontrib>Cucharero Martín, Javier</creatorcontrib><creatorcontrib>Estival Monteliú, Pablo</creatorcontrib><creatorcontrib>Ropero Gradilla, Paloma</creatorcontrib><creatorcontrib>Ferrer Benito, Sara</creatorcontrib><creatorcontrib>Martín Hernández, María Paz</creatorcontrib><creatorcontrib>González Fernández, Fernando Ataulfo</creatorcontrib><creatorcontrib>Gómez Álvarez, Miguel</creatorcontrib><creatorcontrib>Villegas Martínez, Ana</creatorcontrib><creatorcontrib>Benavente Cuesta, Celina</creatorcontrib><creatorcontrib>Martínez Nieto, Jorge</creatorcontrib><title>Largest comparison between onset and relapses of acquired thrombotic thrombocytopenic purpura reveals severe neurological involvement and worse analytic parameters at debut</title><title>Annals of hematology</title><addtitle>Ann Hematol</addtitle><addtitle>Ann Hematol</addtitle><description>It has been proposed that the onset of Acquired Thrombotic Thrombocytopenic Purpura (iTTP) is more severe than subsequent relapses; however, existing studies have limitations. We conducted a retrospective observational study to compare analytical and clinical severity of onset and relapse aTTP cases between 2012 and 2023. A total of 370 episodes of aTTP were analyzed, comprising 272 at initial diagnosis and 98 relapses. At onset, analytical parameters indicative of severity (low hemoglobin, low platelet count, and increased LDH) were significantly worse; patients had severe neurological symptoms (
p
<0.001) and ≥ 3 points in the TMA mortality score (
p
<0.001). In conclusion, the onset of aTTP is associated with worse analytical parameters and severe neurological involvement.</description><subject>ADAMTS13 Protein</subject><subject>Anemia</subject><subject>Aphasia</subject><subject>Consciousness</subject><subject>Data collection</subject><subject>Diplopia</subject><subject>Hematology</subject><subject>Hemoglobin</subject><subject>Humans</subject><subject>Ischemia</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Mortality</subject><subject>Nervous system</subject><subject>Observational studies</subject><subject>Oncology</subject><subject>Purpura</subject><subject>Purpura, Thrombotic Thrombocytopenic - diagnosis</subject><subject>Purpura, Thrombotic Thrombocytopenic - therapy</subject><subject>Recurrence</subject><subject>Retrospective Studies</subject><subject>Statistical analysis</subject><issn>0939-5555</issn><issn>1432-0584</issn><issn>1432-0584</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kU2P1SAUhonRONfRP-DCkLhxU-WjULo0E7-Sm7jRNaH09NpJCx2gd-b-J3-k59oZTVxISM4BnvMe4CXkJWdvOWPNu8yYaJqKibpiSsu6untEdryWApemfkx2rJVtpXBckGc5XzPGhanFU3IhjWhalNiRn3uXDpAL9XFeXBpzDLSDcgsQaAwZCnWhpwkmt2TINA7U-Zt1TNDT8iPFuYtl9A-pP5W4QMCNZU04HRYewU2ZZowJaIA1xSkeRu8mOoZjnI4wQ9ia3MaUATM3nc6aeBs3Q4GUqSu0h24tz8mTAdXgxX28JN8_fvh29bnaf_305er9vvJS6FINXmrWccU5gFNG-kYMjeMDA6al9txrJoxvuVMOdM2EYqrvpTFMc9l518pL8mbTXVK8WfF37DxmD9PkAsQ1W9EKrbgx6oy-_ge9jmvCN2yUQNW2RkpslE8x5wSDXdI4u3SynNmzl3bz0qKX9reX9g6LXt1Lr90M_Z-SB_MQkBuQ8SgcIP3t_R_ZXwFJr2Q</recordid><startdate>20240301</startdate><enddate>20240301</enddate><creator>Vegas Villalmanzo, Blanca</creator><creator>Cantera Estefanía, Rodrigo</creator><creator>Muñoz Madrid, Sara</creator><creator>Cerrato Salas, Mariana</creator><creator>Arnaiz Martín, Irene</creator><creator>Molina Pérez, Marta</creator><creator>Sagrista López, Beatriz</creator><creator>Ruiz Ramírez, Yolanda</creator><creator>Cucharero Martín, Javier</creator><creator>Estival Monteliú, Pablo</creator><creator>Ropero Gradilla, Paloma</creator><creator>Ferrer Benito, Sara</creator><creator>Martín Hernández, María Paz</creator><creator>González Fernández, Fernando Ataulfo</creator><creator>Gómez Álvarez, Miguel</creator><creator>Villegas Martínez, Ana</creator><creator>Benavente Cuesta, Celina</creator><creator>Martínez Nieto, Jorge</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>KB0</scope><scope>M0S</scope><scope>M1P</scope><scope>NAPCQ</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20240301</creationdate><title>Largest comparison between onset and relapses of acquired thrombotic thrombocytopenic purpura reveals severe neurological involvement and worse analytic parameters at debut</title><author>Vegas Villalmanzo, Blanca ; Cantera Estefanía, Rodrigo ; Muñoz Madrid, Sara ; Cerrato Salas, Mariana ; Arnaiz Martín, Irene ; Molina Pérez, Marta ; Sagrista López, Beatriz ; Ruiz Ramírez, Yolanda ; Cucharero Martín, Javier ; Estival Monteliú, Pablo ; Ropero Gradilla, Paloma ; Ferrer Benito, Sara ; Martín Hernández, María Paz ; González Fernández, Fernando Ataulfo ; Gómez Álvarez, Miguel ; Villegas Martínez, Ana ; Benavente Cuesta, Celina ; Martínez Nieto, Jorge</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-fc360b1511eea583c72f7a1f0e0636c1c6028c91a5ae6402505dd3880613bca93</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>ADAMTS13 Protein</topic><topic>Anemia</topic><topic>Aphasia</topic><topic>Consciousness</topic><topic>Data collection</topic><topic>Diplopia</topic><topic>Hematology</topic><topic>Hemoglobin</topic><topic>Humans</topic><topic>Ischemia</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Mortality</topic><topic>Nervous system</topic><topic>Observational studies</topic><topic>Oncology</topic><topic>Purpura</topic><topic>Purpura, Thrombotic Thrombocytopenic - 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We conducted a retrospective observational study to compare analytical and clinical severity of onset and relapse aTTP cases between 2012 and 2023. A total of 370 episodes of aTTP were analyzed, comprising 272 at initial diagnosis and 98 relapses. At onset, analytical parameters indicative of severity (low hemoglobin, low platelet count, and increased LDH) were significantly worse; patients had severe neurological symptoms (
p
<0.001) and ≥ 3 points in the TMA mortality score (
p
<0.001). In conclusion, the onset of aTTP is associated with worse analytical parameters and severe neurological involvement.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38279007</pmid><doi>10.1007/s00277-024-05634-x</doi><tpages>3</tpages></addata></record> |
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| ispartof | Annals of hematology, 2024-03, Vol.103 (3), p.725-727 |
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| source | Springer Nature |
| subjects | ADAMTS13 Protein Anemia Aphasia Consciousness Data collection Diplopia Hematology Hemoglobin Humans Ischemia Medicine Medicine & Public Health Mortality Nervous system Observational studies Oncology Purpura Purpura, Thrombotic Thrombocytopenic - diagnosis Purpura, Thrombotic Thrombocytopenic - therapy Recurrence Retrospective Studies Statistical analysis |
| title | Largest comparison between onset and relapses of acquired thrombotic thrombocytopenic purpura reveals severe neurological involvement and worse analytic parameters at debut |
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