Loading…
Comparative clinical study of phosphorous necrosis and medical-related osteonecrosis of the jaws
Background Phosphorous necrosis of the jaw (PNJ) exhibits similar clinical and pathological features as medical-related osteonecrosis of the jaw (MRONJ). This study aims at comparing the similarities and differences between PNJ and MRONJ regarding pathological features and to provide a theoretical b...
Saved in:
| Published in: | Clinical oral investigations 2024-02, Vol.28 (2), p.147-147, Article 147 |
|---|---|
| Main Authors: | , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | |
|---|---|
| cites | cdi_FETCH-LOGICAL-c326t-68c554f571927e7f9e4292f39ea800a1a5f5d77c5a245233fe2aa60abc3421703 |
| container_end_page | 147 |
| container_issue | 2 |
| container_start_page | 147 |
| container_title | Clinical oral investigations |
| container_volume | 28 |
| creator | Xie, Rongju Wang, Weihong Bian, Longchun Qian, Yemei Li, Jingyi Zhang, Hongrong |
| description | Background
Phosphorous necrosis of the jaw (PNJ) exhibits similar clinical and pathological features as medical-related osteonecrosis of the jaw (MRONJ). This study aims at comparing the similarities and differences between PNJ and MRONJ regarding pathological features and to provide a theoretical basis for the clinical diagnosis and management of PNJ.
Material and methods
A retrospective analysis was conducted to assess clinical differences among 38 PNJ patients and 31 MRONJ patients, who were diagnosed and treated between January 2009 and October 2022. Pathological alterations in bone tissue were evaluated using EDS, H&E, Masson, and TRAP staining on five specimens from both MRONJ and PNJ cases; furthermore, immunohistochemistry was used to determine the expression levels of OPG, RANKL, and Runx2. The mandibular coronoid process was removed from individuals with temporomandibular joint ankylosis to serve as a control.
Results
CBCT imaging demonstrated necrotic bone formation in block, strip, or plaque shapes. EDS analysis showed that the calcium/phosphorus ratio in the bone tissue of PNJ and MRONJ was significantly lower than that of the control group (
P
|
| doi_str_mv | 10.1007/s00784-024-05539-z |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_2926520135</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2925771707</sourcerecordid><originalsourceid>FETCH-LOGICAL-c326t-68c554f571927e7f9e4292f39ea800a1a5f5d77c5a245233fe2aa60abc3421703</originalsourceid><addsrcrecordid>eNp9kLtOwzAUhi0EoqXwAgzIEgtLwJc4bkZUcZMqscBsXOeEpkriYCeg9ulxSCmIgcEX6Xzn9_GH0Ckll5QQeeXDNo0jwsISgqfRZg-NacyTiEtJ93_dR-jI-xUhNE4kP0QjPuWChsIYvcxs1Win2-IdsCmLujC6xL7tsjW2OW6W1oflbOdxDcZZX3is6wxXkPVk5KDULWTY-hbsjgid7RLwSn_4Y3SQ69LDyfacoOfbm6fZfTR_vHuYXc8jw1nSRsnUCBHnQtKUSZB5CjFLWc5T0FNCNNUiF5mURmgWC8Z5DkzrhOiF4TGjkvAJuhhyG2ffOvCtqgpvoCx1DWF6FdISwQjlIqDnf9CV7VwdpuspEXxJIgPFBqr_k3eQq8YVlXZrRYnq_avBvwr-1Zd_tQlNZ9vobhEU7Vq-hQeAD4APpfoV3M_b_8R-AvNzkVk</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>2925771707</pqid></control><display><type>article</type><title>Comparative clinical study of phosphorous necrosis and medical-related osteonecrosis of the jaws</title><source>Springer Link</source><creator>Xie, Rongju ; Wang, Weihong ; Bian, Longchun ; Qian, Yemei ; Li, Jingyi ; Zhang, Hongrong</creator><creatorcontrib>Xie, Rongju ; Wang, Weihong ; Bian, Longchun ; Qian, Yemei ; Li, Jingyi ; Zhang, Hongrong</creatorcontrib><description>Background
Phosphorous necrosis of the jaw (PNJ) exhibits similar clinical and pathological features as medical-related osteonecrosis of the jaw (MRONJ). This study aims at comparing the similarities and differences between PNJ and MRONJ regarding pathological features and to provide a theoretical basis for the clinical diagnosis and management of PNJ.
Material and methods
A retrospective analysis was conducted to assess clinical differences among 38 PNJ patients and 31 MRONJ patients, who were diagnosed and treated between January 2009 and October 2022. Pathological alterations in bone tissue were evaluated using EDS, H&E, Masson, and TRAP staining on five specimens from both MRONJ and PNJ cases; furthermore, immunohistochemistry was used to determine the expression levels of OPG, RANKL, and Runx2. The mandibular coronoid process was removed from individuals with temporomandibular joint ankylosis to serve as a control.
Results
CBCT imaging demonstrated necrotic bone formation in block, strip, or plaque shapes. EDS analysis showed that the calcium/phosphorus ratio in the bone tissue of PNJ and MRONJ was significantly lower than that of the control group (
P
< 0.05). Additionally, staining indicated reduced osteoblast counts, disrupted bone trabecular structure, and decreased collagen fiber content in the bone tissues of PNJ and MRONJ. Immunohistochemistry demonstrated that RANKL expression was significantly lower in MRONJ compared to PNJ and control groups (
P
< 0.05). Conversely, Runx2 expression was significantly higher in PNJ than in MRONJ and control groups (
P
< 0.05), and there was no significant difference in OPG expression.
Conclusion
PNJ and MRONJ demonstrate comparable clinical manifestations and pathological traits, although disparities may exist in their underlying exhibit comparable clinical manifestations, pathological traits, and molecular mechanisms.</description><identifier>ISSN: 1436-3771</identifier><identifier>ISSN: 1432-6981</identifier><identifier>EISSN: 1436-3771</identifier><identifier>DOI: 10.1007/s00784-024-05539-z</identifier><identifier>PMID: 38351377</identifier><language>eng</language><publisher>Berlin/Heidelberg: Springer Berlin Heidelberg</publisher><subject>Ankylosis ; Bisphosphonate-Associated Osteonecrosis of the Jaw - pathology ; Bone Density Conservation Agents ; Bone growth ; Bone imaging ; Bones ; Cancellous bone ; Cbfa-1 protein ; Comparative analysis ; Core Binding Factor Alpha 1 Subunit ; Dentistry ; Diphosphonates - therapeutic use ; Gene expression ; Humans ; Immunohistochemistry ; Jaw ; Medical diagnosis ; Medical imaging ; Medicine ; Molecular modelling ; Necrosis ; Osteogenesis ; Osteonecrosis ; Osteoprotegerin ; Patients ; Retrospective Studies ; Temporomandibular Joint Disorders ; TRANCE protein ; Transcription factors</subject><ispartof>Clinical oral investigations, 2024-02, Vol.28 (2), p.147-147, Article 147</ispartof><rights>The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature 2024. Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.</rights><rights>2024. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><cites>FETCH-LOGICAL-c326t-68c554f571927e7f9e4292f39ea800a1a5f5d77c5a245233fe2aa60abc3421703</cites><orcidid>0000-0002-7022-3897</orcidid></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/38351377$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Xie, Rongju</creatorcontrib><creatorcontrib>Wang, Weihong</creatorcontrib><creatorcontrib>Bian, Longchun</creatorcontrib><creatorcontrib>Qian, Yemei</creatorcontrib><creatorcontrib>Li, Jingyi</creatorcontrib><creatorcontrib>Zhang, Hongrong</creatorcontrib><title>Comparative clinical study of phosphorous necrosis and medical-related osteonecrosis of the jaws</title><title>Clinical oral investigations</title><addtitle>Clin Oral Invest</addtitle><addtitle>Clin Oral Investig</addtitle><description>Background
Phosphorous necrosis of the jaw (PNJ) exhibits similar clinical and pathological features as medical-related osteonecrosis of the jaw (MRONJ). This study aims at comparing the similarities and differences between PNJ and MRONJ regarding pathological features and to provide a theoretical basis for the clinical diagnosis and management of PNJ.
Material and methods
A retrospective analysis was conducted to assess clinical differences among 38 PNJ patients and 31 MRONJ patients, who were diagnosed and treated between January 2009 and October 2022. Pathological alterations in bone tissue were evaluated using EDS, H&E, Masson, and TRAP staining on five specimens from both MRONJ and PNJ cases; furthermore, immunohistochemistry was used to determine the expression levels of OPG, RANKL, and Runx2. The mandibular coronoid process was removed from individuals with temporomandibular joint ankylosis to serve as a control.
Results
CBCT imaging demonstrated necrotic bone formation in block, strip, or plaque shapes. EDS analysis showed that the calcium/phosphorus ratio in the bone tissue of PNJ and MRONJ was significantly lower than that of the control group (
P
< 0.05). Additionally, staining indicated reduced osteoblast counts, disrupted bone trabecular structure, and decreased collagen fiber content in the bone tissues of PNJ and MRONJ. Immunohistochemistry demonstrated that RANKL expression was significantly lower in MRONJ compared to PNJ and control groups (
P
< 0.05). Conversely, Runx2 expression was significantly higher in PNJ than in MRONJ and control groups (
P
< 0.05), and there was no significant difference in OPG expression.
Conclusion
PNJ and MRONJ demonstrate comparable clinical manifestations and pathological traits, although disparities may exist in their underlying exhibit comparable clinical manifestations, pathological traits, and molecular mechanisms.</description><subject>Ankylosis</subject><subject>Bisphosphonate-Associated Osteonecrosis of the Jaw - pathology</subject><subject>Bone Density Conservation Agents</subject><subject>Bone growth</subject><subject>Bone imaging</subject><subject>Bones</subject><subject>Cancellous bone</subject><subject>Cbfa-1 protein</subject><subject>Comparative analysis</subject><subject>Core Binding Factor Alpha 1 Subunit</subject><subject>Dentistry</subject><subject>Diphosphonates - therapeutic use</subject><subject>Gene expression</subject><subject>Humans</subject><subject>Immunohistochemistry</subject><subject>Jaw</subject><subject>Medical diagnosis</subject><subject>Medical imaging</subject><subject>Medicine</subject><subject>Molecular modelling</subject><subject>Necrosis</subject><subject>Osteogenesis</subject><subject>Osteonecrosis</subject><subject>Osteoprotegerin</subject><subject>Patients</subject><subject>Retrospective Studies</subject><subject>Temporomandibular Joint Disorders</subject><subject>TRANCE protein</subject><subject>Transcription factors</subject><issn>1436-3771</issn><issn>1432-6981</issn><issn>1436-3771</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2024</creationdate><recordtype>article</recordtype><recordid>eNp9kLtOwzAUhi0EoqXwAgzIEgtLwJc4bkZUcZMqscBsXOeEpkriYCeg9ulxSCmIgcEX6Xzn9_GH0Ckll5QQeeXDNo0jwsISgqfRZg-NacyTiEtJ93_dR-jI-xUhNE4kP0QjPuWChsIYvcxs1Win2-IdsCmLujC6xL7tsjW2OW6W1oflbOdxDcZZX3is6wxXkPVk5KDULWTY-hbsjgid7RLwSn_4Y3SQ69LDyfacoOfbm6fZfTR_vHuYXc8jw1nSRsnUCBHnQtKUSZB5CjFLWc5T0FNCNNUiF5mURmgWC8Z5DkzrhOiF4TGjkvAJuhhyG2ffOvCtqgpvoCx1DWF6FdISwQjlIqDnf9CV7VwdpuspEXxJIgPFBqr_k3eQq8YVlXZrRYnq_avBvwr-1Zd_tQlNZ9vobhEU7Vq-hQeAD4APpfoV3M_b_8R-AvNzkVk</recordid><startdate>20240213</startdate><enddate>20240213</enddate><creator>Xie, Rongju</creator><creator>Wang, Weihong</creator><creator>Bian, Longchun</creator><creator>Qian, Yemei</creator><creator>Li, Jingyi</creator><creator>Zhang, Hongrong</creator><general>Springer Berlin Heidelberg</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>K9.</scope><scope>7X8</scope><orcidid>https://orcid.org/0000-0002-7022-3897</orcidid></search><sort><creationdate>20240213</creationdate><title>Comparative clinical study of phosphorous necrosis and medical-related osteonecrosis of the jaws</title><author>Xie, Rongju ; Wang, Weihong ; Bian, Longchun ; Qian, Yemei ; Li, Jingyi ; Zhang, Hongrong</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c326t-68c554f571927e7f9e4292f39ea800a1a5f5d77c5a245233fe2aa60abc3421703</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2024</creationdate><topic>Ankylosis</topic><topic>Bisphosphonate-Associated Osteonecrosis of the Jaw - pathology</topic><topic>Bone Density Conservation Agents</topic><topic>Bone growth</topic><topic>Bone imaging</topic><topic>Bones</topic><topic>Cancellous bone</topic><topic>Cbfa-1 protein</topic><topic>Comparative analysis</topic><topic>Core Binding Factor Alpha 1 Subunit</topic><topic>Dentistry</topic><topic>Diphosphonates - therapeutic use</topic><topic>Gene expression</topic><topic>Humans</topic><topic>Immunohistochemistry</topic><topic>Jaw</topic><topic>Medical diagnosis</topic><topic>Medical imaging</topic><topic>Medicine</topic><topic>Molecular modelling</topic><topic>Necrosis</topic><topic>Osteogenesis</topic><topic>Osteonecrosis</topic><topic>Osteoprotegerin</topic><topic>Patients</topic><topic>Retrospective Studies</topic><topic>Temporomandibular Joint Disorders</topic><topic>TRANCE protein</topic><topic>Transcription factors</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Xie, Rongju</creatorcontrib><creatorcontrib>Wang, Weihong</creatorcontrib><creatorcontrib>Bian, Longchun</creatorcontrib><creatorcontrib>Qian, Yemei</creatorcontrib><creatorcontrib>Li, Jingyi</creatorcontrib><creatorcontrib>Zhang, Hongrong</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Clinical oral investigations</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Xie, Rongju</au><au>Wang, Weihong</au><au>Bian, Longchun</au><au>Qian, Yemei</au><au>Li, Jingyi</au><au>Zhang, Hongrong</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Comparative clinical study of phosphorous necrosis and medical-related osteonecrosis of the jaws</atitle><jtitle>Clinical oral investigations</jtitle><stitle>Clin Oral Invest</stitle><addtitle>Clin Oral Investig</addtitle><date>2024-02-13</date><risdate>2024</risdate><volume>28</volume><issue>2</issue><spage>147</spage><epage>147</epage><pages>147-147</pages><artnum>147</artnum><issn>1436-3771</issn><issn>1432-6981</issn><eissn>1436-3771</eissn><abstract>Background
Phosphorous necrosis of the jaw (PNJ) exhibits similar clinical and pathological features as medical-related osteonecrosis of the jaw (MRONJ). This study aims at comparing the similarities and differences between PNJ and MRONJ regarding pathological features and to provide a theoretical basis for the clinical diagnosis and management of PNJ.
Material and methods
A retrospective analysis was conducted to assess clinical differences among 38 PNJ patients and 31 MRONJ patients, who were diagnosed and treated between January 2009 and October 2022. Pathological alterations in bone tissue were evaluated using EDS, H&E, Masson, and TRAP staining on five specimens from both MRONJ and PNJ cases; furthermore, immunohistochemistry was used to determine the expression levels of OPG, RANKL, and Runx2. The mandibular coronoid process was removed from individuals with temporomandibular joint ankylosis to serve as a control.
Results
CBCT imaging demonstrated necrotic bone formation in block, strip, or plaque shapes. EDS analysis showed that the calcium/phosphorus ratio in the bone tissue of PNJ and MRONJ was significantly lower than that of the control group (
P
< 0.05). Additionally, staining indicated reduced osteoblast counts, disrupted bone trabecular structure, and decreased collagen fiber content in the bone tissues of PNJ and MRONJ. Immunohistochemistry demonstrated that RANKL expression was significantly lower in MRONJ compared to PNJ and control groups (
P
< 0.05). Conversely, Runx2 expression was significantly higher in PNJ than in MRONJ and control groups (
P
< 0.05), and there was no significant difference in OPG expression.
Conclusion
PNJ and MRONJ demonstrate comparable clinical manifestations and pathological traits, although disparities may exist in their underlying exhibit comparable clinical manifestations, pathological traits, and molecular mechanisms.</abstract><cop>Berlin/Heidelberg</cop><pub>Springer Berlin Heidelberg</pub><pmid>38351377</pmid><doi>10.1007/s00784-024-05539-z</doi><tpages>1</tpages><orcidid>https://orcid.org/0000-0002-7022-3897</orcidid></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 1436-3771 |
| ispartof | Clinical oral investigations, 2024-02, Vol.28 (2), p.147-147, Article 147 |
| issn | 1436-3771 1432-6981 1436-3771 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_2926520135 |
| source | Springer Link |
| subjects | Ankylosis Bisphosphonate-Associated Osteonecrosis of the Jaw - pathology Bone Density Conservation Agents Bone growth Bone imaging Bones Cancellous bone Cbfa-1 protein Comparative analysis Core Binding Factor Alpha 1 Subunit Dentistry Diphosphonates - therapeutic use Gene expression Humans Immunohistochemistry Jaw Medical diagnosis Medical imaging Medicine Molecular modelling Necrosis Osteogenesis Osteonecrosis Osteoprotegerin Patients Retrospective Studies Temporomandibular Joint Disorders TRANCE protein Transcription factors |
| title | Comparative clinical study of phosphorous necrosis and medical-related osteonecrosis of the jaws |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-22T15%3A18%3A41IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Comparative%20clinical%20study%20of%20phosphorous%20necrosis%20and%20medical-related%20osteonecrosis%20of%20the%20jaws&rft.jtitle=Clinical%20oral%20investigations&rft.au=Xie,%20Rongju&rft.date=2024-02-13&rft.volume=28&rft.issue=2&rft.spage=147&rft.epage=147&rft.pages=147-147&rft.artnum=147&rft.issn=1436-3771&rft.eissn=1436-3771&rft_id=info:doi/10.1007/s00784-024-05539-z&rft_dat=%3Cproquest_cross%3E2925771707%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c326t-68c554f571927e7f9e4292f39ea800a1a5f5d77c5a245233fe2aa60abc3421703%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=2925771707&rft_id=info:pmid/38351377&rfr_iscdi=true |