Visible light-induced C(sp 3 )-H azolation of ethers via radical-polar crossover

Reported herein is a photochemical strategy for C(sp )-H azolation of ethers a hydrogen-atom transfer and radical-polar crossover process, offering efficient access to valuable -alkylated azoles under visible-light irradiation. The protocol is metal-free and photocatalyst-free, and exhibits good to...

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Bibliographic Details
Published in:Chemical communications (Cambridge, England) England), 2024-02, Vol.60 (19), p.2669-2672
Main Authors: Huang, Cheng, Qin, Yu-Shu, Wang, Chen-Lu, Xiao, Peng, Tang, Sheng, Liu, Hong-Jun, Wei, Zhenhong, Cai, Hu
Format: Article
Language:English
Subjects:
Alkylation
Crossovers
Ethers
Heterocyclic compounds
Hydrogen atoms
Light irradiation
Substrates
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Summary:Reported herein is a photochemical strategy for C(sp )-H azolation of ethers a hydrogen-atom transfer and radical-polar crossover process, offering efficient access to valuable -alkylated azoles under visible-light irradiation. The protocol is metal-free and photocatalyst-free, and exhibits good to excellent yields and broad substrate scope with regard to azoles. EPR experiments provide evidence for the formation of intermediates formed .
ISSN:1359-7345
1364-548X
DOI:10.1039/d3cc06210d