Asymmetric construction of sulfur(VI)–fluorine cores

Molecules containing a chiral S(VI) moiety have found extensive applications in drug design and organic synthesis, despite a lack of diverse asymmetric methods for their creation. Now, a ligand-mediated process has enabled the production of enantioenriched S(VI)–F motifs, providing a foundation for...

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Bibliographic Details
Published in:Nature chemistry 2024-03, Vol.16 (3), p.304-305
Main Author: Melvin, Patrick R.
Format: Article
Language:English
Subjects:
639/638/403/933
639/638/403/935
639/638/549/933
Analytical Chemistry
Asymmetry
Biochemistry
Chemistry
Chemistry and Materials Science
Chemistry/Food Science
Drug development
Fluorides
Fluorine
Inorganic Chemistry
Ligands
Lithium
News & Views
news-and-views
Organic Chemistry
Physical Chemistry
Reagents
Sulfur
Citations: Items that this one cites
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Summary:Molecules containing a chiral S(VI) moiety have found extensive applications in drug design and organic synthesis, despite a lack of diverse asymmetric methods for their creation. Now, a ligand-mediated process has enabled the production of enantioenriched S(VI)–F motifs, providing a foundation for further stereospecific elaborations.
ISSN:1755-4330
1755-4349
DOI:10.1038/s41557-024-01454-8