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Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents

Four piroxicam metal complexes; NiL2, PtL2, PdL2, and AgL were synthesized and characterized by different techniques with enhanced antibacterial and anticancer activity. Regarding in vitro antimicrobial activity, complex NiL2 displayed potent antibacterial effect against Escherichia coli and Pseudom...

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Published in:Drug development research 2024-04, Vol.85 (2), p.e22156-n/a
Main Authors: Soliman, Aya M., El‐sagheir, Ahmed M. K., Thabet, Momen M., Abdel Hakiem, Ahmed Faried, Aboraia, Ahmed S.
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Aboraia, Ahmed S.
description Four piroxicam metal complexes; NiL2, PtL2, PdL2, and AgL were synthesized and characterized by different techniques with enhanced antibacterial and anticancer activity. Regarding in vitro antimicrobial activity, complex NiL2 displayed potent antibacterial effect against Escherichia coli and Pseudomonas aeruginosa that was 1.9‐folds higher than piroxicam (minimum inhibitory concentration [MIC] = 31.85, 65.32 µM), respectively. In case of G+ve bacteria, complex PtL2 had potent activity on Staphylococcus aureus which was 2.1‐folds higher than piroxicam (MIC = 43.12 µM), while activity of complex AgL against Enterococcus faecalis was threefolds higher than piroxicam (MIC = 74.57 µM. Complexes PtL2 and PdL2 exhibited higher inhibition of DNA gyrase than piroxicam (IC50 = 6.21 µM) in the range of 1.9–1.7‐folds. The in vitro antiproliferative activity depicted that all investigated complexes showed better cytotoxic effect than piroxicam, specifically Pt and Pd complexes which had lower IC50 values than piroxicam on human liver cancer cell line HepG2 by 1.8 and 1.7‐folds, respectively. While Pd and Ag complexes showed 2 and 1.6‐folds better effect on human colon cancer cell line HT‐29 compared with piroxicam. Molecular modeling studies including docking on Stranded DNA Duplex (1juu) and DNA gyrase enzyme (1kzn) that gave good insight about interaction of complexes with target molecules, calculation of electrostatic potential map and global reactivity descriptors were performed.
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subjects Anti-Bacterial Agents - pharmacology
Antibacterial activity
Anticancer properties
Antimicrobial activity
Antineoplastic Agents - pharmacology
Antineoplastic drugs
Antitumor activity
bacterial infection
Cancer
Chemical synthesis
Colon cancer
Coordination Complexes - pharmacology
Coordination compounds
Cytotoxicity
Deoxyribonucleic acid
DNA
DNA Gyrase
DNA topoisomerase
E coli
Electrostatic properties
Hepatocytes
Humans
Liver cancer
Metal complexes
Microbial Sensitivity Tests
Minimum inhibitory concentration
Modelling
Molecular Docking Simulation
molecular modeling
Molecular modelling
Nickel
Palladium
Piroxicam
Piroxicam - pharmacology
Platinum
repurposing
Silver
title Synthesis, characterization, molecular modeling studies, and biological evaluation of metal piroxicam complexes (M = Ni(II), Pt(IV), Pd(II), Ag(I)) as antibacterial and anticancer agents
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