A new ratiometric fluorescent probe for rapid and highly selective detection of Cysteine in bovine serum

As one of the most fundamental thiol compounds in the human body, cysteine (Cys) is involved in maintaining redox balance. Abnormal Cys levels can lead to various diseases. In this work, we successfully synthesized a fluorescent probe (CTBA) that can specifically detect Cys using acrylate as the rea...

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Bibliographic Details
Published in:Analytical sciences 2024-04, Vol.40 (4), p.765-772
Main Authors: Li, Changjian, Ji, Peng, Liu, Xin, Feng, Guodong, Song, Zhiguang, Guo, Yupeng
Format: Article
Language:English
Subjects:
Analytical Chemistry
Chemistry
Chemistry and Materials Science
Original Paper
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Summary:As one of the most fundamental thiol compounds in the human body, cysteine (Cys) is involved in maintaining redox balance. Abnormal Cys levels can lead to various diseases. In this work, we successfully synthesized a fluorescent probe (CTBA) that can specifically detect Cys using acrylate as the reaction site, and CTBA has met the selectivity and anti-interference for Cys detection under optimized conditions. The linear range for Cys detection is between 0.05 and 100 μM and the detection limit is 0.0381 μM. Finally, this probe is used to detect the Cys content in three bovine serum samples and the test results are satisfactory. Graphical abstract
ISSN:0910-6340
1348-2246
DOI:10.1007/s44211-024-00516-8