EGF‐driven EGFR/miR‐27b‐3p/FOXO1 promotes rat FSH synthesis and secretion

The adenopituitary secretes follicle‐stimulating hormone (FSH), which plays a crucial role in regulating the growth, development, and reproductive functions of organisms. Investigating the process of FSH synthesis and secretion can offer valuable insights into potential areas of focus for reproducti...

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Bibliographic Details
Published in:The FASEB journal 2024-02, Vol.38 (4), p.e23469-n/a
Main Authors: Ma, Yi‐Ran, Gao, Wei, Wang, Hao‐Qi, Zhao, Pei‐Sen, Zhang, Yu‐Xin, Wei, Fan‐Hao, Jiang, Hao, Zhang, Jia‐Bao, Yuan, Bao, Gao, Fei
Format: Article
Language:English
Subjects:
Animals
Biological Transport
EGF
Epidermal Growth Factor
ErbB Receptors - genetics
Follicle Stimulating Hormone
FOXO1
FSH
MicroRNAs - genetics
miR‐27b‐3p
pituitary
Rats
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Summary:The adenopituitary secretes follicle‐stimulating hormone (FSH), which plays a crucial role in regulating the growth, development, and reproductive functions of organisms. Investigating the process of FSH synthesis and secretion can offer valuable insights into potential areas of focus for reproductive research. Epidermal growth factor (EGF) is a significant paracrine/autocrine factor within the body, and studies have demonstrated its ability to stimulate FSH secretion in animals. However, the precise mechanisms that regulate this action are still poorly understood. In this research, in vivo and in vitro experiments showed that the activation of epidermal growth factor receptor (EGFR) by EGF induces the upregulation of miR‐27b‐3p and that miR‐27b‐3p targets and inhibits Foxo1 mRNA expression, resulting in increased FSH synthesis and secretion. In summary, this study elucidates the precise molecular mechanism through which EGF governs the synthesis and secretion of FSH via the EGFR/miR‐27b‐3p/FOXO1 pathway. A model of the mechanism by which EGF regulates FSH synthesis and secretion in the rat adenohypophysis through the EGFR/miR‐27b‐3p/FOXO1 pathway.
ISSN:0892-6638
1530-6860
DOI:10.1096/fj.202301970R