Gold Nanoparticles Inhibit the Proliferation of Multiple Myeloma Cells

Gold nanoparticles significantly inhibit proliferation in multiple myeloma cell lines (see figure) in a dose‐dependent manner. Gold‐treated multiple myeloma cells show cell‐cycle arrest in the G1‐phase (the phase when chromosomes prepare for replication) by up‐regulation of cell‐cycle cyclin‐depende...

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Bibliographic Details
Published in:Advanced materials (Weinheim) 2007-03, Vol.19 (5), p.711-716
Main Authors: Bhattacharya, R., Patra, C. R., Verma, R., Kumar, S., Greipp, P. R., Mukherjee, P.
Format: Article
Language:English
Subjects:
Biomedical applications
Bionanotechnology
Gold
inorganic
Nanoparticles
Nanoparticles, inorganic
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Summary:Gold nanoparticles significantly inhibit proliferation in multiple myeloma cell lines (see figure) in a dose‐dependent manner. Gold‐treated multiple myeloma cells show cell‐cycle arrest in the G1‐phase (the phase when chromosomes prepare for replication) by up‐regulation of cell‐cycle cyclin‐dependent kinase inhibitor proteins p21 and p27. Gold nanoparticles do not affect normal peripheral blood mononuclear cells.
ISSN:0935-9648
1521-4095
DOI:10.1002/adma.200602098