Neurological autoantibody prevalence in chronic epilepsy: Clinical and neuropathologic findings

• Published in: Seizure (London, England) England), 2024-02, Vol.115, p.28-35
• Main Authors: Zhou, Kui, Zhang, Le, Shen, Sisi, Lin, Jing-Fang, Wang, Jie-Rui, Zhou, Dong, Li, Jin-Mei, Sima, Xiutian
• Format: Article
• Language: English
• Subjects: Autoimmune antibodies; CD8-positive T-cells; Epilepsy; Febrile seizure; Neuropathology
• ISSN: 1059-1311; 1532-2688
• DOI: 10.1016/j.seizure.2023.12.018

•The prevalence of neuronal antibodies in patients with “chronic” epilepsy is almost one-tenth.•Febrile seizures may be associated with the formation of autoantibodies.•CD8-positive T-cells may play an important role in the process of “chronic” epilepsy. We aimed to explore the prevalence of autoimmune antibodies (Abs) in a large consecutive series with “chronic” epilepsy and without symptoms of autoimmune encephalitis; and to compare the immunopathology of brain tissue from drug-resistant epilepsy (DRE) with and without Abs positivity. Neuronal and glial antibodies were detected in the serum of patients who were admitted to the wards of West China Hospital from October 2016 to September 2019 and had epilepsy by cell-based assays and tissue-based assays. Twenty-one (6.8 %) of 328 patients had positive Ab findings for the following: dipeptidyl-peptidase-like protein-6 (n = 7), contactin-associated protein-like 2 (n = 5), glutamic acid decarboxylase 65 (n = 4), gamma aminobutyric acid beta receptor (n = 2), N-methyl-d-aspartate receptor (n = 2), and dopamine D2 receptor (n = 1). Antibodies were detected in 6.9 % (13/187) of epilepsy people with unknown etiology and 5.6 % (8/141) of patients with known etiology, respectively. Among 190 patients with DRE, 14 (7.3 %) patients were Abs-positive. There was no significant difference between individuals with seropositive and seronegative results in clinical manifestations, except that the history of febrile seizure was significantly more frequent in the seropositive group. Moreover, brain samples from 3 patients with Abs-positive DRE (with DPPX in 2 patients, and CASPR2 in 1 patient) and 18 patients with Abs-negative DRE were analyzed for immunopathology. We found higher expression of CD8-positive T-cells in the hippocampus of Abs-positive DRE group. Neuronal antibodies are potentially involved in the process of “chronic” epilepsy, and CD8-positive T-cells may play an important role in this process.