Potential regulatory role of epigenetic modifications in aging-related heart failure

• Published in: International journal of cardiology 2024-04, Vol.401, p.131858-131858, Article 131858
• Main Authors: Lv, Lin, Chen, QiuYu, Lu, Jing, Zhao, Qi, Wang, HongYan, Li, JiaHao, Yuan, KeYing, Dong, ZengXiang
• Format: Article
• Language: English
• Subjects: Aging; Epigenetic; Heart failure
• ISSN: 0167-5273; 1874-1754
• DOI: 10.1016/j.ijcard.2024.131858

Heart failure (HF) is a serious clinical syndrome and a serious development or advanced stage of various heart diseases. Aging is an independent factor that causes pathological damage in cardiomyopathy and participates in the occurrence of HF at the molecular level by affecting mechanisms such as telomere shortening and mitochondrial dysfunction. Epigenetic changes have a significant impact on the aging process, and there is increasing evidence that genetic and epigenetic changes are key features of aging and aging-related diseases. Epigenetic modifications can affect genetic information by changing the chromatin state without changing the DNA sequence. Most of the genetic loci that are highly associated with cardiovascular diseases (CVD) are located in non-coding regions of the genome; therefore, the epigenetic mechanism of CVD has attracted much attention. In this review, we focus on the molecular mechanisms of HF during aging and epigenetic modifications mediating aging-related HF, emphasizing that epigenetic mechanisms play an important role in the pathogenesis of aging-related CVD and can be used as potential diagnostic and prognostic biomarkers, as well as therapeutic targets. •Epigenetic modification can affect genetic information by changing chromatin state without changing DNA sequence, and most of the genetic loci highly associated with cardiovascular diseases (CVD) are located in the non-coding regions of the genome.•In this review, we will focus on the molecular mechanisms of epigenetic modifications mediating aging-related HF, emphasizing that epigenetic mechanisms play an important role in the pathogenesis of aging-related CVD.•Epigenetic mechanisms can also be used as potential diagnostic and prognostic biomarkers, and even as therapeutic targets.