Advances in membrane-tethered NAC transcription factors in plants

• Published in: Plant science (Limerick) 2024-05, Vol.342, p.112034-112034, Article 112034
• Main Authors: Shu, Lin, Li, Longhui, Jiang, Yuan-Qing, Yan, Jingli
• Format: Article
• Language: English
• Subjects: Membrane-tethered NAC; NTL; Transcription factor; Transcriptional regulation
• ISSN: 0168-9452; 1873-2259
• DOI: 10.1016/j.plantsci.2024.112034

Transcription factors are central components in cell signal transduction networks and are critical regulators for gene expression. It is estimated that approximately 10% of all transcription factors are membrane-tethered. MTFs (membrane-bound transcription factors) are latent transcription factors that are inherently anchored in the cellular membrane in a dormant form. When plants encounter environmental stimuli, they will be released from the membrane by intramembrane proteases or by the ubiquitin proteasome pathway and then were translocated to the nucleus. The capacity to instantly activate dormant transcription factors is a critical strategy for modulating diverse cellular functions in response to external or internal signals, which provides an important transcriptional regulatory network in response to sudden stimulus and improves plant survival. NTLs (NTM1-like) are a small subset of NAC (NAM, ATAF1/2, CUC2) transcription factors, which contain a conserved NAC domain at the N-terminus and a transmembrane domain at the C-terminus. In the past two decades, several NTLs have been identified from several species, and most of them are involved in both development and stress response. In this review, we review the reports and findings on NTLs in plants and highlight the mechanism of their nuclear import as well as their functions in regulating plant growth and stress response. •Summarizes recent advances in the research of membrane-tethered NAC transcription factors.•NTLs contribute to transcriptional regulation during plant growth and development, stress adaption, and defense responses.•The activation strategy of NTLs ensures rapid expression of genes related to response to environmental fluctuations.