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Possibility of intrauterine transmission from mother to fetus/newborn: Systematic review and meta-analysis of diagnostic methods to detect SARS-CoV-2 infection
•Diagnostic methods used to detect SARS-CoV-2 infection in intrauterine transmission.•The most commonly used method to diagnose SARS-CoV-2 infection in studies was the molecular approaches.•Intrauterine transmission of SARS-CoV-2 infection from mother to fetus/newborn is possible. Several studies ha...
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Published in: | European journal of obstetrics & gynecology and reproductive biology 2024-04, Vol.295, p.181-200 |
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Main Authors: | , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites Items that cite this one |
Online Access: | Get full text |
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Summary: | •Diagnostic methods used to detect SARS-CoV-2 infection in intrauterine transmission.•The most commonly used method to diagnose SARS-CoV-2 infection in studies was the molecular approaches.•Intrauterine transmission of SARS-CoV-2 infection from mother to fetus/newborn is possible.
Several studies have reported vertical transmission of SARS-CoV-2; however, information regarding intrauterine transmission based on diagnostic methods to detect SARS-CoV-2 infection is scarce. A systematic review and meta-analysis was conducted to identify and explore the studies that attempt to ascertain the possibility of intrauterine transmission of SARS-CoV-2 infection according to the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA 2020) statement. The results demonstrate that SARS-CoV-2 can be transmitted intrauterine, as detected by clinical manifestations (1.00, 95 % CI: 1.00 – 1.00, 0.51, 95 % CI: 0.22 – 0.80), imaging (0.50, 95 % CI: 0.24 – 0.76, 0.03, 95 % CI: 0.00 – 0.17), molecular (1. 00, 95 % CI: 1.00 – 1.00, 0.92, 95 % CI: 0.77 – 1.00), immunological (0.32, 95 % CI: 0.10 – 0.57, 0.34, 95 % CI: 0.11 – 0.61), and histological approaches (0.79, 95 % CI: 0.52 – 0.98) in maternal and fetal/neonatal specimens, respectively. The possibility of intrauterine transmission of SARS-CoV-2 from mother to fetus/newborn was 41 % (95 % CI 0.37 – 0.45). We might confirm/verify the intrauterine transmission of SARS-CoCV-2 from mother to fetus/newborn. |
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ISSN: | 0301-2115 1872-7654 1872-7654 |
DOI: | 10.1016/j.ejogrb.2024.02.026 |