Clinical characteristics and prognosis of acute myeloid leukemia patients with Runt‐related transcription factor 1 mutation: A single‐center retrospective analysis

This study aimed to investigate the clinical characteristics and prognosis of Runt‐related transcription factor 1 (RUNX1) mutant acute myeloid leukemia (AML) patients by comparing the features of AML patients with or without RUNX1 mutation. We retrospectively analyzed 180 AML patients including 36 A...

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Bibliographic Details
Published in:Hematological oncology 2024-03, Vol.42 (2), p.e3256-n/a
Main Authors: Wang, Lin‐Ya, Li, Yao, Jiang, Qian, Jiang, Hao, Wang, Yu, Xu, Lan‐Ping, Zhang, Xiao‐Hui, Liu, Kai‐Yan, Tang, Fei‐Fei
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Allografts
Hematopoietic stem cells
Leukemia
Leukocytes
Medical prognosis
molecular mutation
Multivariate analysis
Mutants
Mutation
next‐generation sequencing
Prognosis
Risk factors
RUNX1
Runx1 protein
Stem cell transplantation
Survival
Transcription factors
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Summary:This study aimed to investigate the clinical characteristics and prognosis of Runt‐related transcription factor 1 (RUNX1) mutant acute myeloid leukemia (AML) patients by comparing the features of AML patients with or without RUNX1 mutation. We retrospectively analyzed 180 AML patients including 36 AML patients with mutant RUNX1(AML‐RUNX1mut) and 144 AML patients with wild‐type RUNX1(AML‐RUNX1wt) were selected using the case‐pair method(1:4). Compared to AML‐RUNX1wt, AML‐RUNX1mut showed higher frequency of ASXL1 (p 
ISSN:0278-0232
1099-1069
DOI:10.1002/hon.3256