Improving Health Equity in Living Donor Kidney Transplant: Application of an Implementation Science Framework

• Published in: Transplantation proceedings 2024-01, Vol.56 (1), p.68-74
• Main Authors: McElroy, Lisa M., Mohottige, Dinushika, Cooper, Alexandra, Sanoff, Scott, Davis, LaShara A., Collins, Bradley H., Gordon, Elisa J., Wang, Virginia, Boulware, L. Ebony
• Format: Article
• Language: English
• ISSN: 0041-1345; 1873-2623
• DOI: 10.1016/j.transproceed.2023.12.003

•Implementation science frameworks can assist in identifying multi-level drivers of inequities and intervention design and implementation.•The authors applied the Pragmatic Robust Implementation and Sustainability Model framework to assist transplant centers and researchers in improving equity in access to living donor kidney transplants.•The authors propose 4 areas for future research to address knowledge gaps related to multilevel drivers of inequities in living donor kidney transplants. Interventions to improve racial equity in access to living donor kidney transplants (LDKT) have focused primarily on patients, ignoring the contributions of clinicians, transplant centers, and health system factors. Obtaining access to LDKT is a complex, multi-step process involving patients, their families, clinicians, and health system functions. An implementation science framework can help elucidate multi-level barriers to achieving racial equity in LDKT and guide the implementation of interventions targeted at all levels. We adopted the Pragmatic Robust Implementation and Sustainability Model (PRISM), an implementation science framework for racial equity in LDKT. The purpose was to provide a guide for assessment, inform intervention design, and support planning for the implementation of interventions. We applied 4 main PRISM domains to racial equity in LDKT: Organizational Characteristics, Program Components, External Environment, and Patient Characteristics. We specified elements within each domain that consider perspectives of the health system, transplant center, clinical staff, and patients. The applied PRISM framework provides a foundation for the examination of multi-level influences across the entirety of LDKT care. Researchers, quality improvement staff, and clinicians can use the applied PRISM framework to guide the assessment of inequities, support collaborative intervention development, monitor intervention implementation, and inform resource allocation to improve equity in access to LDKT.