A case of esophageal squamous cell carcinoma accompanied by pancreatic and bile duct metastases: Successful treatment starts with an accurate diagnosis

Pancreatic and bile duct metastases from esophageal cancer are extremely rare. We report a case of advanced esophageal cancer successfully treated with chemotherapy, selected on the basis of an accurate pathologic diagnosis. A 69-year-old man with chronic renal dysfunction presented with persistent...

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Bibliographic Details
Published in:Journal of cancer research and therapeutics 2023-10, Vol.19 (7), p.2060-2063
Main Authors: Ito, Yuki, Ikura, Yoshihiro, Sawai, Hiroaki, Osuga, Tatsuya
Format: Article
Language:English
Subjects:
Bile ducts
Cancer
Care and treatment
Chemotherapy
Complications and side effects
Diagnosis
Diagnostic imaging
Digestive system cancer
Drug therapy
Endoscopy
Esophageal cancer
Metastasis
Pancreatic cancer
Squamous cell carcinoma
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Summary:Pancreatic and bile duct metastases from esophageal cancer are extremely rare. We report a case of advanced esophageal cancer successfully treated with chemotherapy, selected on the basis of an accurate pathologic diagnosis. A 69-year-old man with chronic renal dysfunction presented with persistent abdominal pain and anorexia. Upper gastrointestinal endoscopy revealed an irregular-shaped tumor in the lower esophagus. Computed tomography and ultrasonography revealed swollen para-aortic lymph nodes, a pancreatic mass, and distal bile duct stenosis. Histopathological examination showed that all of the lesions were squamous cell carcinoma with unique immunohistochemical characteristics of p40+ and cytokeratin 7+. The final diagnosis was esophageal squamous cell carcinoma accompanied by lymph node, pancreas, and bile duct metastases. Taking his renal dysfunction into consideration, modified FOLFOX was administered as the first-line chemotherapy. The patient survived for 15 months since his first presentation. The favorable outcome was attributed to the accurate diagnosis based on comprehensive tissue sampling.
ISSN:0973-1482
1998-4138
DOI:10.4103/jcrt.jcrt_1891_21