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Effect of robotic gait training on muscle and bone characteristics in spinal cord transected rats
Osteoporosis and loss of muscle mass are secondary issues with spinal cord injury. Robotic gait training has provided evidence of increasing bone density and muscle mass, but its effect on bone strength is undetermined. The purpose of this study was to determine the effect of a 6‐week robotic locomo...
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Published in: | Journal of orthopaedic research 2024-07, Vol.42 (7), p.1519-1526 |
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Main Authors: | , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Citations: | Items that this one cites |
Online Access: | Get full text |
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Summary: | Osteoporosis and loss of muscle mass are secondary issues with spinal cord injury. Robotic gait training has provided evidence of increasing bone density and muscle mass, but its effect on bone strength is undetermined. The purpose of this study was to determine the effect of a 6‐week robotic locomotion training program on skeletal muscle mass and bone characteristics. Twelve female Sprague‐Dawley rats received a mid‐thoracic spinal cord transection at 5 days old and at 3 weeks old were assigned to a Control or Trained Group. The Trained Group performed 5‐min sessions on the Rat Stepper 5 days a week for 6 weeks with 90% of body weight supported. At the end of the 6 weeks, body mass was obtained and right femurs and four lower extremity muscles were harvested. Femur bone mineral density was measured with DXA and mechanical characteristics of the femur were determined via 3‐point bending testing. Independent t‐tests, effects sizes and percent differences were computed between the two groups (p |
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ISSN: | 0736-0266 1554-527X |
DOI: | 10.1002/jor.25810 |