Curcumin-loaded chitosan-based hydrogels accelerating S. aureus-infected wound healing

The damaged skin for some reasons is vulnerable to invasion by bacteria and other harmful microorganisms, leading to delay of the wound healing. In order to promote the infected wound healing, curcumin was loaded with chitosan-based hydrogel was formed through phenylborate ester bonding and its prop...

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Bibliographic Details
Published in:International journal of biological macromolecules 2024-02, Vol.259, p.129111-129111, Article 129111
Main Authors: Bai, Que, Hu, Fangfang, Gou, Siyuan, Gao, Qian, Wang, Shihao, Zhang, Wenhui, Zhang, Yanni, Lu, Tingli
Format: Article
Language:English
Subjects:
Chitosan
Curcumin
Hydrogel
Infected wound healing
ROS reducing
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Summary:The damaged skin for some reasons is vulnerable to invasion by bacteria and other harmful microorganisms, leading to delay of the wound healing. In order to promote the infected wound healing, curcumin was loaded with chitosan-based hydrogel was formed through phenylborate ester bonding and its properties and effects on the S. aureus-infected wound healing was tested. It was found the hydrogel showed good antioxidation on the intracellular reactive oxygen species, inhibition on the growth of S. aureus, and acceleration the infected skin healing. The ablity of hydrogel due to its regulating inflammation, promoting angiogenesis and collagen synthesis in the wound site. This research work suggested that the developed multifunctional hydrogel might be a beneficial treatment for the infected wound healing.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2023.129111