Curcumin-loaded chitosan-based hydrogels accelerating S. aureus-infected wound healing

The damaged skin for some reasons is vulnerable to invasion by bacteria and other harmful microorganisms, leading to delay of the wound healing. In order to promote the infected wound healing, curcumin was loaded with chitosan-based hydrogel was formed through phenylborate ester bonding and its prop...

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Published in:International journal of biological macromolecules 2024-02, Vol.259, p.129111-129111, Article 129111
Main Authors: Bai, Que, Hu, Fangfang, Gou, Siyuan, Gao, Qian, Wang, Shihao, Zhang, Wenhui, Zhang, Yanni, Lu, Tingli
Format: Article
Language:English
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Chitosan
Curcumin
Hydrogel
Infected wound healing
ROS reducing
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container_title International journal of biological macromolecules
container_volume 259
creator Bai, Que
Hu, Fangfang
Gou, Siyuan
Gao, Qian
Wang, Shihao
Zhang, Wenhui
Zhang, Yanni
Lu, Tingli
description The damaged skin for some reasons is vulnerable to invasion by bacteria and other harmful microorganisms, leading to delay of the wound healing. In order to promote the infected wound healing, curcumin was loaded with chitosan-based hydrogel was formed through phenylborate ester bonding and its properties and effects on the S. aureus-infected wound healing was tested. It was found the hydrogel showed good antioxidation on the intracellular reactive oxygen species, inhibition on the growth of S. aureus, and acceleration the infected skin healing. The ablity of hydrogel due to its regulating inflammation, promoting angiogenesis and collagen synthesis in the wound site. This research work suggested that the developed multifunctional hydrogel might be a beneficial treatment for the infected wound healing.
doi_str_mv 10.1016/j.ijbiomac.2023.129111
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subjects Chitosan
Curcumin
Hydrogel
Infected wound healing
ROS reducing
title Curcumin-loaded chitosan-based hydrogels accelerating S. aureus-infected wound healing
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