Perioperative Lymphopenia is Associated with Increased Risk of Recurrence and Worse Survival Following Hepatectomy for Hepatocellular Carcinoma

Introduction Immune dysregulation may be associated with cancer progression. We sought to investigate the prognostic value of perioperative lymphopenia on short- and long-term outcomes among patients undergoing resection of hepatocellular carcinoma (HCC). Methods Patients undergoing resection of HCC...

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Bibliographic Details
Published in:Annals of surgical oncology 2024-04, Vol.31 (4), p.2568-2578
Main Authors: Tsilimigras, Diamantis I., Endo, Yutaka, Ratti, Francesca, Marques, Hugo P., Cauchy, François, Lam, Vincent, Poultsides, George A., Popescu, Irinel, Alexandrescu, Sorin, Martel, Guillaume, Kitago, Minoru, Guglielmi, Alfredo, Hugh, Tom, Aldrighetti, Luca, Gleisner, Ana, Shen, Feng, Endo, Itaru, Pawlik, Timothy M.
Format: Article
Language:English
Subjects:
Cell number
Hepatectomy
Hepatobiliary Tumors
Hepatocellular carcinoma
Liver cancer
Lymphocytes
Lymphopenia
Medicine
Medicine & Public Health
Oncology
Risk factors
Surgery
Surgical Oncology
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Summary:Introduction Immune dysregulation may be associated with cancer progression. We sought to investigate the prognostic value of perioperative lymphopenia on short- and long-term outcomes among patients undergoing resection of hepatocellular carcinoma (HCC). Methods Patients undergoing resection of HCC between 2000 and 2020 were identified using an international database. The incidence and impact of perioperative lymphopenia [preoperative, postoperative day (POD) 1/3/5], defined as absolute lymphocyte count (ALC)
ISSN:1068-9265
1534-4681
DOI:10.1245/s10434-023-14811-7