Temporal hyper-connectivity and frontal hypo-connectivity within gamma band in schizophrenia: A resting state EEG study

The brain network serves as the physiological foundation for information processing of the brain. Many studies have reported abnormalities of gamma oscillations in Schizophrenia. The aim of this study was to investigate the gamma-band connectivity in Schizophrenia patients. We recorded the resting s...

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Bibliographic Details
Published in:Schizophrenia research 2024-02, Vol.264, p.220-230
Main Authors: Chang, Yuan, Wang, Xiaojuan, Liao, Jingmeng, Chen, Sitong, Liu, Xiaoya, Liu, Shuang, Ming, Dong
Format: Article
Language:English
Subjects:
Functional connectivity
Gamma oscillation
Graph theory
Resting state EEG
Schizophrenia
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Summary:The brain network serves as the physiological foundation for information processing of the brain. Many studies have reported abnormalities of gamma oscillations in Schizophrenia. The aim of this study was to investigate the gamma-band connectivity in Schizophrenia patients. We recorded the resting state electroencephalogram (EEG) for 15 schizophrenia patients with refractory auditory hallucinations and 14 healthy controls, with eyes open and closed. The brain network was constructed based on weighted phase lag index for gamma band. Whole scalp metrics (clustering coefficient, global efficiency and local efficiency) and local region metrics (degree and betweenness centrality) in the frontal and temporal lobes were computed. Correlation analyses between network metrics and symptom scales were examined to find associations with symptom severity. Schizophrenia patients had larger global efficiency and local efficiency (p 
ISSN:0920-9964
1573-2509
DOI:10.1016/j.schres.2023.12.017