Trps1 predicts poor prognosis in advanced high grade serous ovarian carcinoma

• Published in: International journal of cancer 2024-05, Vol.154 (9), p.1639-1651
• Main Authors: Wang, Xiaojiang, Sun, Jiandong, Liu, Yue, Lin, Zihang, Jiang, Xia, Ye, Yuhong, Lv, Chengyu, Lian, Xiuli, Xu, Weiwei, Luo, Shanshan, Liao, Shumin, Chen, Zhangting, Wang, Shie
• Format: Article
• Language: English
• Subjects: Biomarkers; Cell cycle; Cell proliferation; Gene expression; Genetic engineering; high grade serous ovarian carcinoma; Medical prognosis; Ovarian cancer; Ovarian carcinoma; Pathology; phosphoserine transaminase 1; Prognosis; Transcription factors; trichorhinophalangeal syndrome 1; Tumorigenesis
• ISSN: 0020-7136; 1097-0215
• DOI: 10.1002/ijc.34844

TRPS1 is aberrantly expressed in a variety of tumors, including breast, prostate, and gastric cancers, and is strongly associated with tumorigenesis or prognosis. However, the role of TRPS1 in high grade serous ovarian carcinoma (HGSC) is unknown. We investigated the relationship between TRPS1 expression and clinicopathology in HGSC patients. The tumor‐related regulatory mechanisms of TRPS1 was explored through in vivo and vitro experiments. The results showed that TRPS1 was highly expressed in HGSC compared to normal tissues. It was also linked to the cell proliferation index Ki67 and poor prognosis. In vivo experiments showed that knockdown of TRPS1 could inhibit tumor growth. In vitro experiments, knockdown of TRPS1 inhibited the proliferation of ovarian cancer cells. TRPS1 exerted its regulatory role as a transcription factor, binding to the PSAT1 promoter and promoting the expression of PSAT1 gene. Meanwhile, PSAT1 was positively correlated with CCND1 expression. These results suggest that TRPS1 affects HGSC proliferation and cell cycle by regulating PSAT1 and thus CCND1 expression. What's new? The GATA transcription factor family member, TRPS1 can promote or repress the expression of downstream genes to regulate tumor cell cycle, apoptosis, invasion, and metastasis. However, the role of TRPS1 in high‐grade serous ovarian carcinoma is unknown. This study indicates that TRPS1 is highly expressed in high‐grade serous ovarian carcinoma compared to normal tissues, and is associated with the cell proliferation index, Ki67 and poor prognosis. Moreover, TRPS1 affects high‐grade serous ovarian carcinoma proliferation and cell cycle by regulating PSAT1, and thus CCND1 expression. The findings may provide new potential avenues for the clinical treatment of HGSC.