Evaluation and Application of Frailty Index in Colorectal Cancer: A Comprehensive Review

Colorectal cancer (CRC) is a common malignant tumor that primarily affects the elderly population. Surgery is one of the main treatment modalities for CRC. Frailty is a prevalent characteristic among the elderly and a leading cause of mortality. The frailty index (FI) is a comprehensive tool for ass...

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Published in:The American Surgeon 2024-06, Vol.90 (6), p.1630-1637
Main Authors: Jiang, Wenliang, Yu, Huan, Yujun Liu, Xun, Feng, Ma, Zhengkang, Yang, Jiacheng, Wang, Aimei, Wang, Honggang
Format: Article
Language:English
Subjects:
Aged
Colorectal Neoplasms - complications
Colorectal Neoplasms - mortality
Colorectal Neoplasms - surgery
Frail Elderly
Frailty - complications
Frailty - diagnosis
Geriatric Assessment - methods
Humans
Nutritional Status
Postoperative Complications - epidemiology
Prognosis
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Summary:Colorectal cancer (CRC) is a common malignant tumor that primarily affects the elderly population. Surgery is one of the main treatment modalities for CRC. Frailty is a prevalent characteristic among the elderly and a leading cause of mortality. The frailty index (FI) is a comprehensive tool for assessing patients’ frailty status, quantifying indicators such as weight loss, fatigue, and nutritional status, to reflect the degree of frailty. In recent years, the FI has undergone modifications to more accurately evaluate the risk of surgical complications and prognosis in CRC patients. This review summarizes the methods for frailty assessment, the development and modifications of the FI, and compiles the research findings and applications of the FI in predicting surgical complications, postoperative recovery, and survival rates in CRC patients. Furthermore, limitations in the current modified frailty index (mFI) and future research directions are discussed. This review provides essential references for further understanding the role of frailty in CRC patients and the clinical application of the mFI.
ISSN:0003-1348
1555-9823
DOI:10.1177/00031348241227191