The prevalence and odds of bipolar disorder in women with polycystic ovary syndrome (PCO) disease: a systematic review and meta-analysis

• Published in: Archives of women's mental health 2024-06, Vol.27 (3), p.329-336
• Main Authors: Shahraki, Zahra, Rastkar, Mohsen, Ramezanpour, Mohammad-Reza, Ghajarzadeh, Mahsa
• Format: Article
• Language: English
• Subjects: Bipolar disorder; Bipolar Disorder - epidemiology; Bipolar Disorder - psychology; Comorbidity; Female; Health risks; Humans; Medicine; Medicine & Public Health; Meta-analysis; Ovaries; Polycystic ovary syndrome; Polycystic Ovary Syndrome - complications; Polycystic Ovary Syndrome - epidemiology; Polycystic Ovary Syndrome - psychology; Prevalence; Psychiatry; Psychotherapy; Review Article; Systematic review; Womens health
• ISSN: 1434-1816; 1435-1102; 1435-1102
• DOI: 10.1007/s00737-024-01420-w

Background Women with polycystic ovary syndrome (PCO) suffer from psychological difficulties like bipolar disorder. Various studies in the literature report several prevalence rates of bipolar disorder in women with PCO, while there is no systematic review in this field. So, we designed this systematic review and meta-analysis to estimate the pooled prevalence and odds of bipolar disorder in women with PCO disease. Method PubMed, Scopus, EMBASE, Web of Science, Google Scholar, and references of the references, conference abstracts were comprehensively searched by two independent researchers. The search was done on May 1st, 2023. Results A literature search revealed 438 records, 35 full texts were evaluated, and finally, 11 studies remained for systematic review. Totally, 73,102 women with PCO and 340,724 controls were evaluated. Among cases, 1471 had bipolar diagnosis vs. 4321 controls. The prevalence of bipolar disorder in women with PCO ranged between 0 and 27%, and the pooled prevalence was estimated as 4% (95% CI, 2–5%; I 2 , 99.3%, p