Transdermal application of H100 gel to the penile shaft in patients with Peyronie’s disease infiltrates the tunica albuginea

Treatment options for Peyronie’s disease (PD) remain limited. Topical H100 gel, (Hybrid Medical, Edina, USA), which contains nicardipine, super oxide dismutase and emu oil showed safety and efficacy in a previous small double-blind placebo-controlled pilot study. The present study evaluates if topic...

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Bibliographic Details
Published in:International journal of impotence research 2024-04, Vol.36 (2), p.107-109
Main Authors: Twidwell, Jeffry, Mahon, Joseph, Tortorelis, Dean, Levine, Laurence
Format: Article
Language:English
Subjects:
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Clinical outcomes
Clinical trials
Connective tissue diseases
Humans
Male
Medicine
Medicine & Public Health
Nicardipine - analysis
Nicardipine - therapeutic use
Penile Induration - drug therapy
Penile Induration - surgery
Penis
Penis - surgery
Perspective
Pilot Projects
Randomized Controlled Trials as Topic
Reproductive Medicine
rology
Superoxide Dismutase
Topical medication
Urological surgery
Urology
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Summary:Treatment options for Peyronie’s disease (PD) remain limited. Topical H100 gel, (Hybrid Medical, Edina, USA), which contains nicardipine, super oxide dismutase and emu oil showed safety and efficacy in a previous small double-blind placebo-controlled pilot study. The present study evaluates if topically applied H100 gel applied to the penile shaft infiltrates the tunica albuginea. Nicardipine is a key active ingredient in H100 and serves as a surrogate marker. Three men already scheduled to undergo a planned surgical procedure for PD applied commercially available H100 gel twice daily to the penile shaft for up to 30 days prior to the procedure. Tunica albuginea samples were obtained at surgery. Nicardipine evaluation was performed using isotope dilution technique via liquid-chromatograph-mass spectrometry (LCMS). All three patients tolerated H100 gel application without side effects. All three tunica albuginea specimens showed detectable nicardipine in the tunical tissue. Transdermal application of commercially available H100 gel is able to penetrate the tunica albuginea tissue and is detectable in men with acute and chronic PD. This finding may support the encouraging results found in the prior H100 pilot study.
ISSN:0955-9930
1476-5489
DOI:10.1038/s41443-023-00819-w