Air pollutants, genetic susceptibility, and abdominal aortic aneurysm risk: a prospective study

Air pollutants are important contributors to cardiovascular diseases, but associations between long-term exposure to air pollutants and the risk of abdominal aortic aneurysm (AAA) are still unknown. This study was conducted using a sample of 449 463 participants from the UK Biobank. Hazard ratios an...

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Bibliographic Details
Published in:European heart journal 2024-03, Vol.45 (12), p.1030-1039
Main Authors: Ma, Yudiyang, Li, Dankang, Cui, Feipeng, Wang, Jianing, Tang, Linxi, Yang, Yingping, Liu, Run, Tian, Yaohua
Format: Article
Language:English
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Summary:Air pollutants are important contributors to cardiovascular diseases, but associations between long-term exposure to air pollutants and the risk of abdominal aortic aneurysm (AAA) are still unknown. This study was conducted using a sample of 449 463 participants from the UK Biobank. Hazard ratios and 95% confidence intervals for the risk of AAA incidence associated with long-term exposure to air pollutants were estimated using the Cox proportional hazards model with time-varying exposure measurements. Additionally, the cumulative incidence of AAA was calculated by using the Fine and Grey sub-distribution hazards regression model. Furthermore, this study investigated the combined effects and interactions between air pollutants exposure and genetic predisposition in relation to the risk of AAA onset. Long-term exposure to particulate matter with an aerodynamic diameter
ISSN:0195-668X
1522-9645
DOI:10.1093/eurheartj/ehad886