Specific association between retinal neural layer thinning and neurological soft signs in schizophrenia

There is growing evidence of disproportionate retinal thinning in schizophrenia, but doubts are still raised regarding its significance in the context of the neurobiology of the disease. Therefore, we examined whether these abnormalities are significantly associated with neurological soft signs (NSS...

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Published in:European archives of psychiatry and clinical neuroscience 2024-08, Vol.274 (5), p.1237-1240
Main Authors: Krukow, Paweł, Domagała, Adam, Silverstein, Steven M.
Format: Article
Language:English
Subjects:
Adult
Archives & records
Cross-Sectional Studies
Demography
Diabetes
Female
Humans
Illnesses
Male
Medicine
Medicine & Public Health
Mental disorders
Middle Aged
Motor ability
Neurodevelopmental disorders
Neurosciences
Patients
Psychiatry
Retina
Retina - diagnostic imaging
Retina - pathology
Schizophrenia
Schizophrenia - complications
Schizophrenia - pathology
Schizophrenia - physiopathology
Short Communication
Software
Thinning
Tomography
Tomography, Optical Coherence
Young Adult
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Summary:There is growing evidence of disproportionate retinal thinning in schizophrenia, but doubts are still raised regarding its significance in the context of the neurobiology of the disease. Therefore, we examined whether these abnormalities are significantly associated with neurological soft signs (NSS) which are closely related to the risk of schizophrenia. This cross-sectional study analyzing linear correlations between variables involved 56 schizophrenia inpatients and 60 controls. The results confirmed such relationships, and only in the patient sample. In addition, retinal abnormalities and NSS were significantly correlated with duration of illness. These findings provide further evidence for linked neurodevelopmental and neurodegenerative aspects of schizophrenia.
ISSN:0940-1334
1433-8491
1433-8491
DOI:10.1007/s00406-023-01742-3