Engineered keratin/bFGF hydrogel to promote diabetic wound healing in rats

Keratin materials are promising in wound healing acceleration, however, it is a challenge for the keratin to efficiently therapy the impaired wound healing, such as diabetic foot ulcers. Here, we report a keratin/bFGF hydrogel for skin repair of chronic wounds in diabetic rats based on their charact...

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Published in:International journal of biological macromolecules 2024-03, Vol.261 (Pt 1), p.129725-129725, Article 129725
Main Authors: Sun, Changfa, Huang, Yuqian, Wang, Lili, Deng, Jia, Qing, Rui, Ge, Xin, Han, Xue, Zha, Guodong, Pu, Wei, Wang, Bochu, Hao, Shilei
Format: Article
Language:English
Subjects:
angiogenesis
Animals
bFGF
cadherins
cell adhesion
cell proliferation
Diabetes Mellitus, Experimental - drug therapy
diabetic foot
Diabetic Foot - drug therapy
Diabetic foot ulcer
extracellular matrix
fibronectins
hairs
Humans
Hydrogel dressing
hydrogels
Hydrogels - pharmacology
Hydrogels - therapeutic use
keratin
Keratin 31
Keratins - pharmacology
Rats
therapeutics
Tissue repair
vimentin
Wound Healing
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Summary:Keratin materials are promising in wound healing acceleration, however, it is a challenge for the keratin to efficiently therapy the impaired wound healing, such as diabetic foot ulcers. Here, we report a keratin/bFGF hydrogel for skin repair of chronic wounds in diabetic rats based on their characteristics of extracellular matrix and growth factor degradation in diabetic ulcer. Recombinant keratin 31 (K31), the most abundant keratin in human hair, exhibited the highly efficient performances in cell adhesion, proliferation and migration. More importantly, the introduction of bFGF into K31 hydrogel significantly enhances the properties of cell proliferation, wound closure acceleration, angiogenesis and skin appendages regeneration. Furthermore, the combination of K31 and bFGF can promote epithelial-mesenchymal transition by inhibiting the expression of E-cadherin and promoting the expression of vimentin and fibronectin. These findings demonstrate the engineered K31/bFGF hydrogel as a promising therapeutic agent for diabetic wound healing.
ISSN:0141-8130
1879-0003
DOI:10.1016/j.ijbiomac.2024.129725