Photosensitizer‐loaded hydrogels: A new antibacterial dressing

• Published in: Wound repair and regeneration 2024-05, Vol.32 (3), p.301-313
• Main Authors: Liu, Shunying, Feng, Yanhai, Tan, Yang, Chen, Jinyi, Yang, Tao, Wang, Xiaoyu, Li, Lingfei, Wang, Fangjie, Liang, Huaping, Zhong, Julia‐Li, Qi, Chao, Lei, Xia
• Format: Article
• Language: English
• Subjects: Anti-Bacterial Agents - administration & dosage; Anti-Bacterial Agents - pharmacology; antibacterial photodynamic therapy; Bacterial Infections - drug therapy; bacteria‐infected wounds; Bandages; Humans; Hydrogels - pharmacology; Photochemotherapy - methods; photosensitizer‐loaded hydrogels; Photosensitizing Agents - pharmacology; Wound Healing - drug effects; Wound Infection - drug therapy; Wound Infection - microbiology
• ISSN: 1067-1927; 1524-475X; 1524-475X
• DOI: 10.1111/wrr.13156

Bacterial wound infection has emerged as a pivotal threat to human health worldwide, and the situation has worsened owing to the gradual increase in antibiotic‐resistant bacteria caused by the improper use of antibiotics. To reduce the use of antibiotics and avoid the increase in antibiotic‐resistant bacteria, researchers are increasingly paying attention to  photodynamic therapy, which uses light to produce reactive oxygen species to kill bacteria. Treating bacteria‐infected wounds by photodynamic therapy requires fixing the photosensitizer (PS) at the wound site and maintaining a certain level of wound humidity. Hydrogels are materials with a high water content and are well suited for fixing PSs at wound sites for antibacterial photodynamic therapy. Therefore, hydrogels are often loaded with PSs for treating bacteria‐infected wounds via antibacterial photodynamic therapy. In this review, we systematically summarised the antibacterial mechanisms and applications of PS‐loaded hydrogels for treating bacteria‐infected wounds via photodynamic therapy. In addition, the recent  studies and the research status progresses of novel antibacterial hydrogels are discussed. Finally, the challenges and future prospects of PS‐loaded hydrogels are reviewed.