Prospective, randomized, clinical trial on the effects of laparoscopic insufflation pressures on portal pressures in dogs

• Published in: Veterinary surgery 2024-05, Vol.53 (4), p.613-619
• Main Authors: Parlier, Mark, Thomson, Christopher B., Rendahl, Aaron, Strelchik, Alena, Baldo, Caroline, Eckman, Sarah K., Krueger, Amy, Gordon‐Evans, Wanda J.
• Format: Article
• Language: English
• Subjects: Animals; Dogs; Female; Hemodynamics; Insufflation - methods; Insufflation - veterinary; Laparoscopy; Laparoscopy - methods; Laparoscopy - veterinary; Male; Pneumoperitoneum, Artificial - methods; Pneumoperitoneum, Artificial - veterinary; Portal Pressure; Pressure; Pressure effects; Prospective Studies; Statistical analysis
• ISSN: 0161-3499; 1532-950X
• DOI: 10.1111/vsu.14074

Objective The adverse effects of intra‐abdominal pressure from capnoperitoneum on cardiovascular and pulmonary systems have been well documented, but the effects on portal pressures in dogs with various insufflation pressures is poorly defined. The aim of the present study was to measure the effect of a range of insufflation pressures on the portal pressure, using direct pressure measurements in patients undergoing laparoscopy. Study design Clinical randomized prospective study. Animals Nine client‐owned dogs undergoing routine laparoscopy. Methods Two rounds of direct portal pressure assessments were performed, at insufflation pressures of 0, 6, 10, and 14 mmHg in a predetermined randomized sequence. The data were analyzed for effects of insufflation pressure, hemodynamic alterations, and round. A best‐fit exponential model of the relationship between portal pressure and insufflation pressure was created. Results Portal pressure increased by 38% at 6 mmHg, 95% at 10 mmHg, and 175% at 14 mmHg compared to baseline. Portal pressure increased at an average rate of 7.45% per mmHg of insufflation pressure. Effects of weight, weight/insufflation pressure interaction, and round of insufflation were not statistically significant. No systemic hemodynamic adverse events were observed. Conclusion Portal pressure increased as insufflation pressure increased. There was no clinically significant difference in baseline portal pressure between rounds of insufflation. Clinical significance This exponential model of portal pressure supports the use of the minimum insufflation pressure to allow visualization during laparoscopy. The return of portal pressure to baseline following desufflation supports the comparison of portal pressure measurements before and after laparoscopic shunt attenuation.