Topical Hemostatic Agents and Risk of Postoperative Hemorrhage After Transoral Robotic Surgery

• Published in: Ear, nose, & throat journal nose, & throat journal, 2024-02, p.1455613241233097-1455613241233097
• Main Authors: Maza, Guillermo, Sharma, Arun
• Format: Article
• Language: English
• ISSN: 0145-5613; 1942-7522
• DOI: 10.1177/01455613241233097

Postoperative hemorrhage is the most common complication of transoral robotic surgery (TORS). The available research literature on topical hemostatic agents is deficient, despite their wide use. This study aims to evaluate the frequency and severity of hemorrhagic events after TORS procedures, performed with various topical hemostatic agents. This study was planned as a retrospective review to identify postoperative hemorrhage events in a database of all consecutive adult patients who required TORS from January 1, 2015, to April 1, 2020. All procedures were performed in one single institution by the same surgeon. In 2017, bovine gelatin matrix with thrombin (BgMT) was replaced by the porcine gelatin matrix with thrombin (PgMT) for all procedures. Postoperative hemorrhage was identified, along with hemostatic agents employed and other variables. Results: A cohort of 80 TORS procedures was obtained from a population of 78 individuals (60 males:18 females). BgMT was used in 28 procedures (35%), and five cases of postoperative hemorrhage were identified (17.8%), two of them were severe. PgMT was used in 52 procedures (65%) just observing one minor hemorrhagic event (1.92%). Although a significant difference was observed for total events between groups ( = .0183), there was no difference between major or severe hemorrhagic events ( = .1196). The overall rate of major and severe postoperative hemorrhage in the study population was 2.5% (n = 80). This is the first study to evaluate topical hemostatic agents during TORS procedures. The PgMT group had a reduced incidence of total postoperative hemorrhages, although there was no difference in the number of severe hemorrhagic events. The overall simplicity and cost-effectiveness of these agents would support their use, particularly considering the potential risk associated with airway hemorrhage.